The syndrome of abnormal chromatin clumping in leucocytes: a myelodysplastic disorder with proliferative features?

• Published in: British journal of haematology Vol. 70; no. 1; p. 49
• Main Authors: Felman, P, Bryon, P A, Gentilhomme, O, Ffrench, M, Charrin, C, Espinouse, D, Viala, J J
• Format: Journal Article
• Language: English
• Published: England 01.09.1988
• Subjects: Aged; Bone Marrow - ultrastructure; Chromatin - ultrastructure; Female; Granulocytes - ultrastructure; Humans; Leukocytes - ultrastructure; Male; Microscopy, Electron; Middle Aged; Myelodysplastic Syndromes - pathology

Five patients presenting extremely exaggerated chromatin clumping in leucocytes, associated with a loss of segmentation, are described. Peripheral cytopenia, a high percentage of circulating immature granulocytes (chiefly myelocytes) with variable leucocytosis, marrow hypercellularity with granulocy...