Immunoglobulin light chain levels can be used to determine disease stage in children with juvenile idiopathic arthritis

• Published in: Clinical laboratory science Vol. 24; no. 2; pp. 93 - 98
• Main Authors: Kutulculer, Necil, Karaca, Neslihan E, Azarsiz, Elif, Aksu, Guzide, Gulez, Nesrin
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Laboratory Science 2011
• Subjects: Acute-Phase Proteins - immunology; Arthritis, Juvenile - immunology; Biomarkers - blood; Blood Sedimentation; C-Reactive Protein; Care and treatment; Case-Control Studies; Child; Children; Diagnosis; Familial Mediterranean Fever - immunology; Female; Health aspects; Health technology assessment; Humans; Immunoglobulin G - blood; Immunoglobulin kappa-Chains - blood; Immunoglobulin lambda-Chains - blood; Immunoglobulin M - blood; Immunoglobulins; Juvenile arthritis; Male; Measurement; Prospective Studies; Reference Values; Serum Amyloid A Protein - analysis; Turkey

Patients with some inflammatory diseases have been shown to have increased levels of immunoglobulin light chains. In this study, we measured the concentrations of immunoglobulin kappa and lambda light chains in sera of patients with juvenile idiopathic arthritis (JIA) (study group), familial mediter...