Asthmatic subjects with allergy have elevated levels of IgE+ B cells in the airways
To The Editor: Allergic asthma is an IgE-mediated disease whereby inhaled allergens cross-link membrane-bound IgE on the surfaces of mast cells and basophils, inducing the activation and release of proinflammatory mediators, and driving type-2 inflammation and the manifestation of clinical symptoms....
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Published in | Journal of allergy and clinical immunology Vol. 140; no. 2; pp. 590 - 593.e9 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
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01.08.2017
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Abstract | To The Editor: Allergic asthma is an IgE-mediated disease whereby inhaled allergens cross-link membrane-bound IgE on the surfaces of mast cells and basophils, inducing the activation and release of proinflammatory mediators, and driving type-2 inflammation and the manifestation of clinical symptoms.1 Because B cells solely produce IgE, it is evident that these cells play a crucial role in initiating allergen-induced inflammatory processes. The frequency and absolute numbers of IgG+ B cells, evaluated as a control cell population, showed a higher tendency, but no statistical difference in asthmatic subjects compared with the nonasthmatic subjects when measured in the sputum or blood (P > .05) (see Fig E6 in this article's Online Repository at www.jacionline.org). Variable Controls (n = 10) Asthmatic subjects with allergy (n = 18) Subjects with allergy (n = 19) Sex (M/F), no. 4/6 8/10 10/9 Age (y) 37.1 ± 3.8 31.8 ± 3.3 26.2 ± 2.4 FEV1, % of predicted 94.9 ± 2.6 91.6 ± 1.6 98.2 ± 2.8 Methacholine PC20 (mg/mL), geometric mean (95% CI) >16 3.7 (2.2, 6.4)∗† >16 Sputum eosinophils (%) 0.08 ± 0.04 1.8 ± 0.3∗† 0.6 ± 0.1 Sputum total IgE (IU/mL) 0.5 ± 0.0 3.7 ± 1.3∗ 0.8 ± 0.2 Sputum BAFF (pg/mL) 32.8 ± 12.3 230.3 ± 53.4∗† 24.0 ± 7.0 Blood eosinophils (%) 1.8 ± 0.4 4.8 ± 0.5∗ 3.2 ± 0.4 Plasma total IgE (IU/mL) 19.8 ± 3.4 288.7 ± 34.3∗† 107.6 ± 29.9 Skin test positive to Cat dander 0 15 12 Horse dander 0 12 5 House... |
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AbstractList | To The Editor: Allergic asthma is an IgE-mediated disease whereby inhaled allergens cross-link membrane-bound IgE on the surfaces of mast cells and basophils, inducing the activation and release of proinflammatory mediators, and driving type-2 inflammation and the manifestation of clinical symptoms.1 Because B cells solely produce IgE, it is evident that these cells play a crucial role in initiating allergen-induced inflammatory processes. The frequency and absolute numbers of IgG+ B cells, evaluated as a control cell population, showed a higher tendency, but no statistical difference in asthmatic subjects compared with the nonasthmatic subjects when measured in the sputum or blood (P > .05) (see Fig E6 in this article's Online Repository at www.jacionline.org). Variable Controls (n = 10) Asthmatic subjects with allergy (n = 18) Subjects with allergy (n = 19) Sex (M/F), no. 4/6 8/10 10/9 Age (y) 37.1 ± 3.8 31.8 ± 3.3 26.2 ± 2.4 FEV1, % of predicted 94.9 ± 2.6 91.6 ± 1.6 98.2 ± 2.8 Methacholine PC20 (mg/mL), geometric mean (95% CI) >16 3.7 (2.2, 6.4)∗† >16 Sputum eosinophils (%) 0.08 ± 0.04 1.8 ± 0.3∗† 0.6 ± 0.1 Sputum total IgE (IU/mL) 0.5 ± 0.0 3.7 ± 1.3∗ 0.8 ± 0.2 Sputum BAFF (pg/mL) 32.8 ± 12.3 230.3 ± 53.4∗† 24.0 ± 7.0 Blood eosinophils (%) 1.8 ± 0.4 4.8 ± 0.5∗ 3.2 ± 0.4 Plasma total IgE (IU/mL) 19.8 ± 3.4 288.7 ± 34.3∗† 107.6 ± 29.9 Skin test positive to Cat dander 0 15 12 Horse dander 0 12 5 House... |
Author | Salter, Brittany M. Gauvreau, Gail M. Munoz, Caroline E. Watson, Rick M. Scime, Tara Obminski, Caitlin D. Smith, Steven G. Oliveria, John-Paul Phan, Stephanie Sehmi, Roma |
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Cites_doi | 10.1136/thx.30.1.2 10.1111/j.1365-2222.1982.tb03120.x 10.1056/NEJM197510092931507 10.1111/j.1398-9995.2006.01305.x 10.1046/j.1365-2249.2002.02025.x 10.3109/02770903.2011.617477 10.1111/j.1365-2222.1977.tb01448.x 10.1111/all.12563 10.1038/nri1181 10.1183/09031936.05.00034805 10.1034/j.1399-3003.2000.15.11.x 10.1126/scitranslmed.3008961 10.1164/ajrccm.153.2.8564094 10.1183/13993003.00536-2015 10.1164/ajrccm.154.2.8756799 10.1164/ajrccm.165.1.2010112 10.1159/000237349 10.1371/journal.pone.0161161 |
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end-page: 831 ident: bib1 article-title: Allergen-induced airway responses publication-title: Eur Respir J contributor: fullname: O'Byrne – volume: 153 start-page: 540 year: 1996 end-page: 544 ident: bib4 article-title: Elevated B cells in sputum of asthmatics: close correlation with eosinophils publication-title: Am J Respir Crit Care Med contributor: fullname: Dolovich – volume: 3 start-page: 721 year: 2003 end-page: 732 ident: bib9 article-title: The regulation of immunoglobulin E class-switch recombination publication-title: Nat Rev Immunol contributor: fullname: Brodeur – volume: 70 start-page: 420 year: 2015 end-page: 428 ident: bib5 article-title: IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis publication-title: Allergy contributor: fullname: Davies – volume: 130 start-page: 370 year: 2002 end-page: 378 ident: bib10 article-title: Detection and characterization of plasma cells in peripheral blood: 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article-title: Allergen-induced airway responses publication-title: Eur Respir J doi: 10.1183/13993003.00536-2015 contributor: fullname: Gauvreau – volume: 154 start-page: 308 year: 1996 ident: 10.1016/j.jaci.2016.12.981_bibE7 article-title: Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.154.2.8756799 contributor: fullname: Pizzichini – volume: 165 start-page: 22 year: 2002 ident: 10.1016/j.jaci.2016.12.981_bib3 article-title: Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.165.1.2010112 contributor: fullname: Wilson – volume: 111 start-page: 77 year: 1996 ident: 10.1016/j.jaci.2016.12.981_bib7 article-title: Culture and IgE synthesis of nasal B cells publication-title: Int Arch Allergy Immunol doi: 10.1159/000237349 contributor: fullname: Zürcher – volume: 11 start-page: e0161161 year: 2016 ident: 10.1016/j.jaci.2016.12.981_bib8 article-title: Precursor B cells increase in the lung during airway allergic inflammation: a role for B cell-activating factor publication-title: PLoS One doi: 10.1371/journal.pone.0161161 contributor: fullname: Samitas |
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SubjectTerms | Allergens Allergens - immunology Allergies Asthma Asthma - complications Asthma - diagnosis Asthma - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomarkers Blood BLyS protein Cell Membrane - immunology Cell Membrane - metabolism Dander Eosinophils Humans Hypersensitivity - complications Hypersensitivity - diagnosis Hypersensitivity - immunology Immunoglobulin E Immunoglobulin E - immunology Immunoglobulin E - metabolism Immunoglobulin G Immunoglobulins Inflammation Leukocytes (basophilic) Leukocytes (eosinophilic) Lymphocyte Count Lymphocyte receptors Lymphocytes Lymphocytes B Mast cells Methacholine Respiratory System - immunology Respiratory System - metabolism Skin tests Sputum Sputum - immunology Sputum - metabolism Surface chemistry T cell receptors |
Title | Asthmatic subjects with allergy have elevated levels of IgE+ B cells in the airways |
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