Pharmacometabolomics uncovers key metabolic changes in the first-in-human study of β-lapachone derivative - Jang, Yeonseo; Kang, Jihyun; Li, Yufei; Chae, Woori; Yang, Eunsol; Lee, SeungHwan; Cho, Joo-Youn (Metabolomics, 2025)
Keywords: Adult; Biochemistry; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Cell Biology; Chromatography; Correlation analysis; Developmental Biology; Enzymes; Female; Genotypes; Hepatitis; Humans; Inflammation; Lapachone; Life Sciences; Lipid metabolism; Male; Metabolic Networks and Pathways - drug effects; Metabolic pathways; Metabolism; Metabolites; Metabolome - drug effects; Metabolomics; Metabolomics - methods; Molecular Medicine; NAD(P)H Dehydrogenase (Quinone) - genetics; NAD(P)H Dehydrogenase (Quinone) - metabolism; NADPH dehydrogenase; Naphthoquinones - metabolism; Naphthoquinones - pharmacokinetics; Naphthoquinones - pharmacology; Original; Original Article; Pharmacodynamics; Plasma; Side effects; Statistical analysis; Therapeutic targets; Toxicity; Variance analysis; Young Adult; United States--US; Austria; NQO1; Metabolites; WK0202; Nrf2; Arginine biosynthesis