Effect of tablet splitting on serum cholesterol concentrations
To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin. A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simvastatin or atorvasta...
Saved in:
Published in | The Annals of pharmacotherapy Vol. 36; no. 2; p. 205 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.2002
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin.
A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simvastatin or atorvastatin between January 1999 and November 2000.
Veterans Affairs Medical Center in Huntington, WV.
Patients were included if they were taking simvastatin or atorvastatin with regular lipid management and follow-up laboratory results. Patients were required to remain on the same milligram-per-day dose at least 6-8 weeks before and after tablet-splitting initiation and have cholesterol values drawn at least 6 weeks after initiation of both whole-tablet and half-tablet dosing. Patients were excluded if they had a triglyceride level > 400 mg/dL or were noncompliant on the basis of pharmacy records and provider notes. MEASUREMENT OUTCOMES: The primary end points were changes in total cholesterol and LDL cholesterol values before and after the patient was switched to half-tablet therapy.
The overall results for this review demonstrated no statistically significant increase in total cholesterol and LDL cholesterol concentrations. Total cholesterol and LDL cholesterol values actually decreased from presplitting to postsplitting, p = 0.017 and p = 0.003, respectively.
The investigation showed that half-tablet dosing was as effective as whole-tablet dosing. The program will be continued as a part of quality patient care at the Huntington Veterans Affairs Medical Center. |
---|---|
AbstractList | To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and atorvastatin.
A retrospective chart review of total cholesterol and LDL cholesterol values of patients instructed to split simvastatin or atorvastatin between January 1999 and November 2000.
Veterans Affairs Medical Center in Huntington, WV.
Patients were included if they were taking simvastatin or atorvastatin with regular lipid management and follow-up laboratory results. Patients were required to remain on the same milligram-per-day dose at least 6-8 weeks before and after tablet-splitting initiation and have cholesterol values drawn at least 6 weeks after initiation of both whole-tablet and half-tablet dosing. Patients were excluded if they had a triglyceride level > 400 mg/dL or were noncompliant on the basis of pharmacy records and provider notes. MEASUREMENT OUTCOMES: The primary end points were changes in total cholesterol and LDL cholesterol values before and after the patient was switched to half-tablet therapy.
The overall results for this review demonstrated no statistically significant increase in total cholesterol and LDL cholesterol concentrations. Total cholesterol and LDL cholesterol values actually decreased from presplitting to postsplitting, p = 0.017 and p = 0.003, respectively.
The investigation showed that half-tablet dosing was as effective as whole-tablet dosing. The program will be continued as a part of quality patient care at the Huntington Veterans Affairs Medical Center. |
Author | Castle, Sharon S Streetman, Daniel S Duncan, Megan C |
Author_xml | – sequence: 1 givenname: Megan C surname: Duncan fullname: Duncan, Megan C organization: Veterans Affairs Medical Center, Huntington, WV, USA – sequence: 2 givenname: Sharon S surname: Castle fullname: Castle, Sharon S – sequence: 3 givenname: Daniel S surname: Streetman fullname: Streetman, Daniel S |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11847935$$D View this record in MEDLINE/PubMed |
BookMark | eNo1z7tOwzAUgGEPRfQCAy-A_AIp59hOYi9IVVUuUiUWmCvbOaZBiR3F7sDbMwDTv33Sv2aLmCIxdoewRanqBzudt7gTUi7YCqGBCoSGJVvn_AUABoW5ZktErVoj6xV7PIRAvvAUeLFuoMLzNPSl9PGTp8gzzZeR-3MaKBea08B9ip5imW3pU8w37CrYIdPtXzfs4-nwvn-pjm_Pr_vdsfJSiVIForZT0hskbMHXQrSm076GIImc905jY7TrHAJpj7WV1qpWKildAwqM2LD7X3e6uJG60zT3o52_T_8j4gfcx0n2 |
CitedBy_id | crossref_primary_10_1016_j_clinthera_2011_02_009 crossref_primary_10_1111_tmi_12309 crossref_primary_10_1590_S0103_21002011000100011 crossref_primary_10_1007_s12272_011_0717_8 crossref_primary_10_1177_107424840300800205 crossref_primary_10_3390_ph16010008 crossref_primary_10_1016_j_amjcard_2005_02_019 crossref_primary_10_1007_s40005_012_0030_7 crossref_primary_10_1177_001857870403900807 crossref_primary_10_1177_001857870303800513 crossref_primary_10_1097_01_AOG_0000365943_34401_28 crossref_primary_10_1016_j_ijpharm_2007_08_041 crossref_primary_10_1007_s40272_016_0193_1 crossref_primary_10_1016_j_clinthera_2015_08_015 crossref_primary_10_15406_ppij_2022_10_00359 crossref_primary_10_4140_TCP_n_2012_421 crossref_primary_10_1111_j_1759_8893_2010_00020_x crossref_primary_10_37667_pk_2002_57 crossref_primary_10_1592_phco_22_13_1110_33518 crossref_primary_10_1016_j_ijpharm_2016_12_032 crossref_primary_10_52494_FTLZ3502 crossref_primary_10_3399_BJGPO_2022_0001 crossref_primary_10_1111_j_1365_2648_2010_05477_x crossref_primary_10_3389_fped_2021_747499 crossref_primary_10_1016_j_jsps_2011_12_009 crossref_primary_10_1016_j_ejps_2003_10_018 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1345/aph.1A233 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology |
ExternalDocumentID | 11847935 |
Genre | Journal Article |
GeographicLocations | West Virginia |
GeographicLocations_xml | – name: West Virginia |
GroupedDBID | --- -TM .GJ 01A 0R~ 0VX 1CY 23M 39C 4.4 53G 54M 5GY 5RE 6J9 6PF AABMB AACKU AACMV AACTG AADTT AADUE AAEWN AAGGD AAGMC AAJIQ AAJOX AAJPV AAKGS AAMGE AANSI AAPEO AAQQT AAQXH AARDL AARIX AATAA AATBZ AAUAS AAWTL AAXOT AAYOK AAYTG AAZBJ ABAWP ABCCA ABDWY ABEIX ABFWQ ABHKI ABJIS ABJNI ABKRH ABLUO ABOCM ABPGX ABPNF ABQKF ABQXT ABRHV ABVFX ABVVC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFO ACGFS ACGZU ACJER ACJTF ACLFY ACLHI ACLZU ACOFE ACOXC ACROE ACSBE ACSIQ ACTQU ACUAV ACUIR ACXKE ACXMB ADBBV ADEIA ADMPF ADNBR ADRRZ ADTBJ ADUKL ADZZY AECGH AECVZ AEDTQ AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEUIJ AEWDL AEWHI AEXFG AEXNY AFEET AFFNX AFKBI AFKRG AFMOU AFQAA AFUIA AGKLV AGNHF AGWFA AHJOV AIGRN AIIQI AIOMO AIZAD AJABX AJEFB AJMMQ AJSCY AJUZI AJXAJ ALKWR ALMA_UNASSIGNED_HOLDINGS ALTZF AMCVQ ANDLU ARTOV AUTPY AUVAJ AYAKG B8M BBRGL BDDNI BKIIM BKSCU BPACV BSEHC BWJAD CBRKF CDWPY CFDXU CGR CORYS CQQTX CS3 CUTAK CUY CVF DB0 DC- DC. DC0 DD- DD0 DE- DE. DF0 DN0 DO- DOPDO DV7 EBS ECM EIF EJD EMOBN F5P FHBDP GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION H13 HZ~ J5H J8X JCYGO K.F L7B LSO M4V NPM O9- P.9 P.B P2P Q1R ROL S01 SCNPE SFC SHG SJN SPQ SPV THW UDS WH7 YCJ ZGI ZONMY ZPPRI ZRKOI ZSSAH ZXP |
ID | FETCH-LOGICAL-c342t-fee7d43c91e170c52279d8c50f3eebccb81698bdb10e8c15a3aa473433b604092 |
ISSN | 1060-0280 |
IngestDate | Sat Sep 28 07:36:30 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c342t-fee7d43c91e170c52279d8c50f3eebccb81698bdb10e8c15a3aa473433b604092 |
PMID | 11847935 |
ParticipantIDs | pubmed_primary_11847935 |
PublicationCentury | 2000 |
PublicationDate | 2002-02-01 |
PublicationDateYYYYMMDD | 2002-02-01 |
PublicationDate_xml | – month: 02 year: 2002 text: 2002-02-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Annals of pharmacotherapy |
PublicationTitleAlternate | Ann Pharmacother |
PublicationYear | 2002 |
SSID | ssj0009129 |
Score | 1.8719555 |
Snippet | To evaluate the effects of tablet splitting on low-density lipoprotein (LDL) cholesterol and total cholesterol values in patients taking simvastatin and... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 205 |
SubjectTerms | Atorvastatin Calcium Cholesterol - blood Cholesterol, LDL - blood Cross-Over Studies Drug Costs Female Heptanoic Acids - administration & dosage Heptanoic Acids - economics Heptanoic Acids - pharmacology Humans Male Middle Aged Pyrroles - administration & dosage Pyrroles - economics Pyrroles - pharmacology Retrospective Studies Simvastatin - administration & dosage Simvastatin - economics Simvastatin - pharmacology Tablets West Virginia |
Title | Effect of tablet splitting on serum cholesterol concentrations |
URI | https://www.ncbi.nlm.nih.gov/pubmed/11847935 |
Volume | 36 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JS8QwGA0uFy_ivksO4mWmmjTptLkIIooIiocRvA1JmiqCnQHrQX-9X5a2M6PiAqWUpg1p3-ORfMn3gtBBapKMGCqiONMk4ipJIlHkKtKCCJ0SaaRf5XvTu7zjV_fJfbtnq8suqdSRfv8yr-Q_qMI9wNVmyf4B2aZSuAHXgC-cAWE4_wrjYD1sp_ltBlTVeYEuZVjIXHagCa_PHStvzg1haI1ASr8Ys43SPbVsab2UR8HPupq0HIDOrvbx0mvzALrQBFjPpJ0sdoFUeNMqUBO4cZPeIcrq09lDYR1piOvFyY04kh6J7FTsuHp6-5LAknhcCl069WeJZty6WcjR4xE9jb0JxhhUo2eHFQx7bMgv-bl0yi27LppFs2lmFe_GRm9qE2bqdq1rviM4TUGLjpv2WBfZUMfUSMP1OPpLaDEMFfCpx30ZzZhyBR3eemzeurjfps69dPEhvm1dyN9W0YknBx4W2JMDN-TAwxI7cuAxcuBJcqyhu4vz_tllFDbLiDTjcRUVxqQ5Z1pQQ1OiE-sMmWc6IQUzRmmtMtoTmcoVJSbTNJFMSp4yzpjqgZCLeB3NlcPSbCJMJOU0VULnRcElM0LBIeB5w2Oak3wLbfj_Mhh5R5RB_ce2vy3ZQQstpXbRfAGENnvQn6vUvgPpA6RxTAo |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+tablet+splitting+on+serum+cholesterol+concentrations&rft.jtitle=The+Annals+of+pharmacotherapy&rft.au=Duncan%2C+Megan+C&rft.au=Castle%2C+Sharon+S&rft.au=Streetman%2C+Daniel+S&rft.date=2002-02-01&rft.issn=1060-0280&rft.volume=36&rft.issue=2&rft.spage=205&rft_id=info:doi/10.1345%2Faph.1A233&rft_id=info%3Apmid%2F11847935&rft_id=info%3Apmid%2F11847935&rft.externalDocID=11847935 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1060-0280&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1060-0280&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1060-0280&client=summon |