14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease

• Published in: International journal of molecular sciences Vol. 20; no. 14; p. 3518
• Main Authors: Fan, Xiaolan, Cui, Lang, Zeng, Yao, Song, Wenhao, Gaur, Uma, Yang, Mingyao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.07.2019; MDPI
• Subjects: 14-3-3 Proteins - metabolism; Aging; Aging - metabolism; Animals; Binding sites; Breast cancer; Chronic illnesses; Disease; Gene expression; Heat shock proteins; Humans; Kinases; Leukemia; Medical prognosis; Metabolism; Metastasis; Neoplasms - metabolism; Neurodegenerative Diseases - metabolism; Phosphorylation; Prostate; Review; Signal transduction; Tumors; 14-3-3 proteins; neurodegenerative diseases; adaptor; chaperone-like; cancer; aging

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 protein...