14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 protein...

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Published inInternational journal of molecular sciences Vol. 20; no. 14; p. 3518
Main Authors Fan, Xiaolan, Cui, Lang, Zeng, Yao, Song, Wenhao, Gaur, Uma, Yang, Mingyao
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.07.2019
MDPI
Subjects
14-3-3 Proteins - metabolism
Aging
Aging - metabolism
Animals
Binding sites
Breast cancer
Chronic illnesses
Disease
Gene expression
Heat shock proteins
Humans
Kinases
Leukemia
Medical prognosis
Metabolism
Metastasis
Neoplasms - metabolism
Neurodegenerative Diseases - metabolism
Phosphorylation
Prostate
Review
Signal transduction
Tumors
14-3-3 proteins
neurodegenerative diseases
adaptor
chaperone-like
cancer
aging
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Abstract 14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 proteins act as molecular chaperones, preventing the aggregation of unfolded proteins under conditions of cellular stress. Furthermore, 14-3-3 proteins have been shown to have similar expression patterns in tumors, aging, and neurodegenerative diseases. Therefore, we put forward the idea that the adaptor activity and chaperone-like activity of 14-3-3 proteins might play a substantial role in the above-mentioned conditions. Interestingly, 14-3-3 proteins are considered to be standing at the crossroads of cancer, aging, and age-related neurodegenerative diseases. There are great possibilities to improve the above-mentioned diseases and conditions through intervention in the activity of the 14-3-3 protein family.
AbstractList 14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 proteins act as molecular chaperones, preventing the aggregation of unfolded proteins under conditions of cellular stress. Furthermore, 14-3-3 proteins have been shown to have similar expression patterns in tumors, aging, and neurodegenerative diseases. Therefore, we put forward the idea that the adaptor activity and chaperone-like activity of 14-3-3 proteins might play a substantial role in the above-mentioned conditions. Interestingly, 14-3-3 proteins are considered to be standing at the crossroads of cancer, aging, and age-related neurodegenerative diseases. There are great possibilities to improve the above-mentioned diseases and conditions through intervention in the activity of the 14-3-3 protein family.14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 proteins act as molecular chaperones, preventing the aggregation of unfolded proteins under conditions of cellular stress. Furthermore, 14-3-3 proteins have been shown to have similar expression patterns in tumors, aging, and neurodegenerative diseases. Therefore, we put forward the idea that the adaptor activity and chaperone-like activity of 14-3-3 proteins might play a substantial role in the above-mentioned conditions. Interestingly, 14-3-3 proteins are considered to be standing at the crossroads of cancer, aging, and age-related neurodegenerative diseases. There are great possibilities to improve the above-mentioned diseases and conditions through intervention in the activity of the 14-3-3 protein family.
Aging is also associated with considerable alterations in internal homeostasis, especially in the immune and endocrine systems, which play a significant role in cancer control. [...]aging and carcinogenesis are coupled to each other at the molecular level [3]. By analyzing the transcriptomic data set covering 531 samples at five different time points of aging, Peer et al. found that the aging-associated changes in transcriptomic expression and the transformation characteristics of chronic degenerative diseases (cardiovascular, metabolic, and neurodegenerative diseases) are related to each other and are different from the gene expression characteristics associated with cancer [4]. Cancer Much work has been dedicated to understand the role of 14-3-3 proteins in cancer. Because of the lack of significant catalytic activity, the contribution of 14-3-3 proteins to cancer is primarily related to the regulation of oncoproteins and tumor suppressor proteins. The promoter regions of 14-3-3σ gene displayed abnormal methylation in breast, lung, liver, ovarian, bladder, and prostate cancers [82,83,84,85,86]. [...]14-3-3σ methylation can be used as a diagnostic indicator for these tumors [32].
14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 proteins act as molecular chaperones, preventing the aggregation of unfolded proteins under conditions of cellular stress. Furthermore, 14-3-3 proteins have been shown to have similar expression patterns in tumors, aging, and neurodegenerative diseases. Therefore, we put forward the idea that the adaptor activity and chaperone-like activity of 14-3-3 proteins might play a substantial role in the above-mentioned conditions. Interestingly, 14-3-3 proteins are considered to be standing at the crossroads of cancer, aging, and age-related neurodegenerative diseases. There are great possibilities to improve the above-mentioned diseases and conditions through intervention in the activity of the 14-3-3 protein family.
Author Song, Wenhao
Cui, Lang
Gaur, Uma
Fan, Xiaolan
Zeng, Yao
Yang, Mingyao
AuthorAffiliation 1 Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China
2 Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31323761$$D View this record in MEDLINE/PubMed
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Keywords 14-3-3 proteins
neurodegenerative diseases
adaptor
chaperone-like
cancer
aging
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Snippet 14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of...
Aging is also associated with considerable alterations in internal homeostasis, especially in the immune and endocrine systems, which play a significant role...
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SubjectTerms 14-3-3 Proteins - metabolism
Aging
Aging - metabolism
Animals
Binding sites
Breast cancer
Chronic illnesses
Disease
Gene expression
Heat shock proteins
Humans
Kinases
Leukemia
Medical prognosis
Metabolism
Metastasis
Neoplasms - metabolism
Neurodegenerative Diseases - metabolism
Phosphorylation
Prostate
Review
Signal transduction
Tumors
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Title 14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease
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