Sirt1 Promotes DNA Damage Repair and Cellular Survival

• Published in: Biomolecules & therapeutics Vol. 19; no. 3; pp. 282 - 287
• Main Authors: Song, Seung-Hyun, Lee, Mi-Ok, Lee, Ji-Seon, Oh, Je-Sok, Cho, Sung-Uk, Cha, Hyuk-Jin
• Format: Journal Article
• Language: English
• Published: 한국응용약물학회 31.07.2011
• Subjects: 약학

Sirt1, a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, is known to deacetylate a number of proteins that are involved in various cellular pathways such as the stress response, apoptosis and cell growth. Modulation of the stress response by Sirtuin 1 (Sirt1) is achieved by t...