Early and Mid-Term Disposition of α-PVP and its unknown Metabolites in Urine and Oral Fluid Through a Multi-Analytical Hyphenated Approach Following a Single Non-Controlled Administration to Healthy Volunteers

• Published in: The AAPS journal Vol. 27; no. 1; p. 25
• Main Authors: Di Trana, Annagiulia, La Maida, Nunzia, de la Rosa, Georgina, Di Giorgi, Alessandro, Graziano, Silvia, Aldhaehri, Khaled, Papaseit, Esther, Hladun, Olga, Farré, Magí, Pérez, Clara, Pichini, Simona
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 09.01.2025
• Subjects: Adult; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Chromatography, Liquid - methods; Female; Gas Chromatography-Mass Spectrometry - methods; Healthy Volunteers; Humans; Male; Pharmacology/Toxicology; Pharmacy; Psychotropic Drugs - administration & dosage; Psychotropic Drugs - metabolism; Psychotropic Drugs - pharmacokinetics; Psychotropic Drugs - urine; Pyrrolidines - administration & dosage; Pyrrolidines - metabolism; Pyrrolidines - pharmacokinetics; Pyrrolidines - urine; Research Article; Saliva - chemistry; Saliva - metabolism; Tandem Mass Spectrometry - methods; Young Adult; GC–MS/MS; pharmacokinetics; metabolism; α-PVP; LC-ESI-HRMS/MS; synthetic cathinones

Nowadays, synthetic cathinones (SCs) is the second more representative subclass of New Psychoactive Substances, accounting for 104 analogues in the illegal market. Since its first report in 2011, α-pyrrolidinovalerophenone (α-PVP) gained popularity among drug users, provoking an increased number of...