Early and Mid-Term Disposition of α-PVP and its unknown Metabolites in Urine and Oral Fluid Through a Multi-Analytical Hyphenated Approach Following a Single Non-Controlled Administration to Healthy Volunteers - Di Trana, Annagiulia; La Maida, Nunzia; de la Rosa, Georgina; Di Giorgi, Alessandro; Graziano, Silvia; Aldhaehri, Khaled; Papaseit, Esther; Hladun, Olga; Farré, Magí; Pérez, Clara; Pichini, Simona (The AAPS journal, 2025)
Keywords: Adult; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Chromatography, Liquid - methods; Female; Gas Chromatography-Mass Spectrometry - methods; Healthy Volunteers; Humans; Male; Pharmacology/Toxicology; Pharmacy; Psychotropic Drugs - administration & dosage; Psychotropic Drugs - metabolism; Psychotropic Drugs - pharmacokinetics; Psychotropic Drugs - urine; Pyrrolidines - administration & dosage; Pyrrolidines - metabolism; Pyrrolidines - pharmacokinetics; Pyrrolidines - urine; Research Article; Saliva - chemistry; Saliva - metabolism; Tandem Mass Spectrometry - methods; Young Adult; GC–MS/MS; pharmacokinetics; metabolism; α-PVP; LC-ESI-HRMS/MS; synthetic cathinones