Investigating the effect of reduced temperatures on the efficacy of rhabdovirus-based viral vector platforms

• Published in: Journal of general virology Vol. 105; no. 8
• Main Authors: Kakish, Julia E., Mehrani, Yeganeh, Kodeeswaran, Arthane, Geronimo, Katrina, Clark, Mary Ellen, van Vloten, Jacob P., Karimi, Khalil, Mallard, Bonnie A., Meng, Baozhong, Bridle, Byram W., Knapp, Jason P.
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 22.08.2024
• Subjects: Animal; Animals; Cell Line; Cell Line, Tumor; Cold Temperature; Genetic Vectors - genetics; Humans; Negative-strand RNA Viruses; Oncolytic Virotherapy - methods; Oncolytic Viruses - genetics; Oncolytic Viruses - physiology; Rhabdoviridae - genetics; Rhabdoviridae - physiology; Temperature; Vesiculovirus - genetics; Vesiculovirus - physiology; Virus Replication; temperature; rhabdovirus; viral vector; oncolytic

Rhabdoviral vectors can induce lysis of cancer cells. While studied almost exclusively at 37 °C, viruses are subject to a range of temperatures in vivo , including temperatures ≤31 °C. Despite potential implications, the effect of temperatures <37 °C on the performance of rhabdoviral vectors is u...