The potential utility of [68 Ga]Ga-DOTA-FAPI-04 as a novel broad-spectrum oncological and non-oncological imaging agent—comparison with [18F]FDG

• Published in: European journal of nuclear medicine and molecular imaging Vol. 49; no. 3; pp. 963 - 979
• Main Authors: Lan, Lianjun, Liu, Hanxiang, Wang, Yingwei, Deng, Jia, Peng, Dengsai, Feng, Yue, Wang, Li, Chen, Yue, Qiu, Lin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2022; Springer Nature B.V
• Subjects: Accuracy; Adult; Aged; Blood cancer; Cardiology; Computed tomography; Female; Fluorine isotopes; Fluorodeoxyglucose F18; Gallium Radioisotopes; Heterocyclic Compounds, 1-Ring; Humans; Imaging; Inflammation; Lesions; Lymphoma; Male; Medical imaging; Medicine; Medicine & Public Health; Metastases; Metastasis; Middle Aged; Multiple Myeloma; Nuclear Medicine; Oncology; Oncology – General; Original Article; Orthopedics; Patients; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Prospective Studies; Quinolines; Radiology; Sensitivity; Solid tumors; Tomography; Tumors; Broad-spectrum imaging agent; [; Fibroblast activation protein (FAP); Ga]Ga-DOTA-FAPI-04; F]FDG; [18F]FDG; [68 Ga]Ga-DOTA-FAPI-04

Purpose This study aimed to compare the detection performance of [ 68  Ga]Ga-DOTA-FAPI-04 and [ 18 F]FDG PET/CT in the patients with various oncological and non-oncological lesions. Methods A total of 123 patients underwent contemporaneous [ 68  Ga]Ga-DOTA-FAPI-04 and [ 18 F]FDG PET/CT were included...