U-73122, a phospholipase C inhibitor, impairs lymphocytic choriomeningitis virus virion infectivity

• Published in: Journal of general virology Vol. 105; no. 12
• Main Authors: Mizuma, Keita, Hashizume, Mei, Urata, Shuzo, Shindo, Keiko, Takashima, Ayako, Mizuta, Satoshi, Iwasaki, Masaharu
• Format: Journal Article
• Language: English
• Published: England 17.12.2024
• Subjects: Animals; Antiviral Agents - pharmacology; Cell Line; Chlorocebus aethiops; Estrenes - pharmacology; Humans; Lassa virus - drug effects; Lymphocytic choriomeningitis virus - drug effects; Lymphocytic choriomeningitis virus - genetics; Lymphocytic choriomeningitis virus - physiology; Pyrrolidinones - pharmacology; Type C Phospholipases - antagonists & inhibitors; Type C Phospholipases - genetics; Type C Phospholipases - metabolism; Vero Cells; Virion - drug effects; Virus Replication - drug effects; virion; Junín virus; LCMV; Lassa virus; antiviral

Lassa virus (LASV) is an Old World (OW) mammarenavirus that causes Lassa fever, a life-threatening acute febrile disease endemic in West Africa. Lymphocytic choriomeningitis virus (LCMV) is a worldwide-distributed, prototypic OW mammarenavirus of clinical significance that has been largely neglected...