Synthesis and Investigation of Pinane-Based Chiral Tridentate Ligands in the Asymmetric Addition of Diethylzinc to Aldehydes

• Published in: Catalysts Vol. 10; no. 5; p. 474
• Main Authors: Raji, Mounir, Le, Tam Minh, Fülöp, Ferenc, Szakonyi, Zsolt
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.05.2020
• Subjects: (–)-β-pinene; 3-methylenenopinone; aminodiols; chiral catalyst; diethylzinc

A library of pinane-based chiral aminodiols, derived from natural (−)-β-pinene, were prepared and applied as chiral catalysts in the addition of diethylzinc to aldehydes. (−)-β-Pinene was reacted to provide 3-methylenenopinone, followed by a reduction of the carbonyl function to give a key allylic a...