Activity of ROCKII not ROCKI promotes pulmonary metastasis of melanoma cells via modulating Smad2/3-MMP9 and FAK-Src-VEGF signalling
Rho-associated coiled-coil kinase (ROCK) inhibition decreases tumourogenic growth, proliferation and angiogenesis. Multifaceted evidences are there about the role of ROCK in cancer progression, but isoform specific analysis in secondary pulmonary melanoma is still unaddressed. This study explored th...
Saved in:
| Published in | Cellular signalling Vol. 97; p. 110389 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Inc
01.09.2022
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Rho-associated coiled-coil kinase (ROCK) inhibition decreases tumourogenic growth, proliferation and angiogenesis. Multifaceted evidences are there about the role of ROCK in cancer progression, but isoform specific analysis in secondary pulmonary melanoma is still unaddressed. This study explored the operating function of ROCK in the metastasis of B16F10 mice melanoma cell line. Inhibition by KD-025 indicated dual wielding role of ROCKII as it is associated with the regulation of MMP9 activity responsible for extra-cellular matrix (ECM) degradation as well as angiogenic invasion as an effect of Src-FAK-STAT3 interaction dependent VEGF switching. We found the assisting role of ROCKII, not ROCKI in nuclear localization of Smads that effectively increased MMP9 expression and activity (p < 0.01). This cleaved the protein components of ECM thereby played a crucial role in tissue remodeling at secondary site during establishment of metastatic tumour. ROCKII phosphorylation at Ser1366 as an activation of the same was imprinted essential for oncogenic molecular bagatelle leading to histo-architectural change of pulmonary tissue with extracellular matrix degradation as a consequence of invasion. Direct correlation of pROCKIISer1366 with MMP9 as well as VEGF expression in vivo studies cue to demonstrate the importance of pROCKIISer1366 inhibition in the context of angiogenesis, and metastasis suggesting ROCKII signaling as a possible target for the treatment of secondary lung cancer specially in metastatic melanoma.
[Display omitted]
•Chief operating role of ROCKII in Src-FAK-STAT3 complex mediated VEGF expression.•ROCKII activation regulates nuclear localization of Smad complex and MMP9 activity.•The p-ROCKII-Ser1366, the active ROCKII is key player for secondary lung melanoma.•KD-025 restricts ECM degradation and angiogenesis in metastatic lung melanoma. |
|---|---|
| AbstractList | Rho-associated coiled-coil kinase (ROCK) inhibition decreases tumourogenic growth, proliferation and angiogenesis. Multifaceted evidences are there about the role of ROCK in cancer progression, but isoform specific analysis in secondary pulmonary melanoma is still unaddressed. This study explored the operating function of ROCK in the metastasis of B16F10 mice melanoma cell line. Inhibition by KD-025 indicated dual wielding role of ROCKII as it is associated with the regulation of MMP9 activity responsible for extra-cellular matrix (ECM) degradation as well as angiogenic invasion as an effect of Src-FAK-STAT3 interaction dependent VEGF switching. We found the assisting role of ROCKII, not ROCKI in nuclear localization of Smads that effectively increased MMP9 expression and activity (p < 0.01). This cleaved the protein components of ECM thereby played a crucial role in tissue remodeling at secondary site during establishment of metastatic tumour. ROCKII phosphorylation at Ser1366 as an activation of the same was imprinted essential for oncogenic molecular bagatelle leading to histo-architectural change of pulmonary tissue with extracellular matrix degradation as a consequence of invasion. Direct correlation of pROCKIISer1366 with MMP9 as well as VEGF expression in vivo studies cue to demonstrate the importance of pROCKIISer1366 inhibition in the context of angiogenesis, and metastasis suggesting ROCKII signaling as a possible target for the treatment of secondary lung cancer specially in metastatic melanoma.
[Display omitted]
•Chief operating role of ROCKII in Src-FAK-STAT3 complex mediated VEGF expression.•ROCKII activation regulates nuclear localization of Smad complex and MMP9 activity.•The p-ROCKII-Ser1366, the active ROCKII is key player for secondary lung melanoma.•KD-025 restricts ECM degradation and angiogenesis in metastatic lung melanoma. Rho-associated coiled-coil kinase (ROCK) inhibition decreases tumourogenic growth, proliferation and angiogenesis. Multifaceted evidences are there about the role of ROCK in cancer progression, but isoform specific analysis in secondary pulmonary melanoma is still unaddressed. This study explored the operating function of ROCK in the metastasis of B16F10 mice melanoma cell line. Inhibition by KD-025 indicated dual wielding role of ROCKII as it is associated with the regulation of MMP9 activity responsible for extra-cellular matrix (ECM) degradation as well as angiogenic invasion as an effect of Src-FAK-STAT3 interaction dependent VEGF switching. We found the assisting role of ROCKII, not ROCKI in nuclear localization of Smads that effectively increased MMP9 expression and activity (p < 0.01). This cleaved the protein components of ECM thereby played a crucial role in tissue remodeling at secondary site during establishment of metastatic tumour. ROCKII phosphorylation at Ser1366 as an activation of the same was imprinted essential for oncogenic molecular bagatelle leading to histo-architectural change of pulmonary tissue with extracellular matrix degradation as a consequence of invasion. Direct correlation of pROCKIISer1366 with MMP9 as well as VEGF expression in vivo studies cue to demonstrate the importance of pROCKIISer1366 inhibition in the context of angiogenesis, and metastasis suggesting ROCKII signaling as a possible target for the treatment of secondary lung cancer specially in metastatic melanoma.Rho-associated coiled-coil kinase (ROCK) inhibition decreases tumourogenic growth, proliferation and angiogenesis. Multifaceted evidences are there about the role of ROCK in cancer progression, but isoform specific analysis in secondary pulmonary melanoma is still unaddressed. This study explored the operating function of ROCK in the metastasis of B16F10 mice melanoma cell line. Inhibition by KD-025 indicated dual wielding role of ROCKII as it is associated with the regulation of MMP9 activity responsible for extra-cellular matrix (ECM) degradation as well as angiogenic invasion as an effect of Src-FAK-STAT3 interaction dependent VEGF switching. We found the assisting role of ROCKII, not ROCKI in nuclear localization of Smads that effectively increased MMP9 expression and activity (p < 0.01). This cleaved the protein components of ECM thereby played a crucial role in tissue remodeling at secondary site during establishment of metastatic tumour. ROCKII phosphorylation at Ser1366 as an activation of the same was imprinted essential for oncogenic molecular bagatelle leading to histo-architectural change of pulmonary tissue with extracellular matrix degradation as a consequence of invasion. Direct correlation of pROCKIISer1366 with MMP9 as well as VEGF expression in vivo studies cue to demonstrate the importance of pROCKIISer1366 inhibition in the context of angiogenesis, and metastasis suggesting ROCKII signaling as a possible target for the treatment of secondary lung cancer specially in metastatic melanoma. |
| ArticleNumber | 110389 |
| Author | Banerjee, Soumi Chakraborty, Pratip Chowdhury, Kaustav Dutta Patra, Debajyoti Sadhukhan, Gobinda Chandra Chatterjee, Sujan Basu, Anupam Ghosh, Pujita |
| Author_xml | – sequence: 1 givenname: Sujan surname: Chatterjee fullname: Chatterjee, Sujan organization: Molecular Biology and Tissue Culture Laboratory, Post Graduate Department of Zoology, Vidyasagar College, Kolkata 700006, India – sequence: 2 givenname: Debajyoti surname: Patra fullname: Patra, Debajyoti organization: Molecular Biology and Tissue Culture Laboratory, Post Graduate Department of Zoology, Vidyasagar College, Kolkata 700006, India – sequence: 3 givenname: Pujita surname: Ghosh fullname: Ghosh, Pujita organization: Cyto-genetics Laboratory, Department of Zoology, Rammohan College, 102/1, Raja Rammohan Sarani, Kolkata 700 009, India – sequence: 4 givenname: Soumi surname: Banerjee fullname: Banerjee, Soumi organization: Cyto-genetics Laboratory, Department of Zoology, Rammohan College, 102/1, Raja Rammohan Sarani, Kolkata 700 009, India – sequence: 5 givenname: Kaustav Dutta surname: Chowdhury fullname: Chowdhury, Kaustav Dutta organization: Cyto-genetics Laboratory, Department of Zoology, Rammohan College, 102/1, Raja Rammohan Sarani, Kolkata 700 009, India – sequence: 6 givenname: Pratip surname: Chakraborty fullname: Chakraborty, Pratip organization: Department of Infertility, Institute of Reproductive Medicine, HB-36/A/3, Salt Lake, Sector-III, Kolkata 700106, India – sequence: 7 givenname: Anupam surname: Basu fullname: Basu, Anupam organization: Molecular Biology and Human Genetics Laboratory, Department of Zoology, The University of Burdwan, Bardhaman 713104, West Bengal, India – sequence: 8 givenname: Gobinda Chandra surname: Sadhukhan fullname: Sadhukhan, Gobinda Chandra email: sadhukhan.g.c@gmail.com organization: UGC-HRDC, Jadavpur University, Kolkata 700032 (Retd.), India |
| BookMark | eNqFkM1qGzEURkVJoU7SRyho2c04-pnRzNBFMSZOTRJSmrZboZGugoxGckeyIfs-eOVOVtkEBFeL71y-e87RWYgBEPpEyZISKq52Sw3eJ_e0ZISxJaWEd_07tKBdyyveU36GFqTru0o0ovuAzlPaEUIbItgC_V3p7I4uP-No8Y-H9e12i0PM8xfvpzjGDAnvD36MQU3PeISsUnkunYgRvApxVPh_A3x0Co_RHLzKLjzhx1EZdsWr-_vvPVbB4M3qtnqcdPX7-maDS-GgvC_BS_TeKp_g48u8QL821z_X36q7h5vtenVXaV6zXA0gKFBWg2gHzjTvB6O1bayqLVPENrQzqhNtP_QlQ4zRStc9UD1YaAdqB36BPs97y11_DpCyHF06NVcB4iFJJtqurQVlokS_zFE9xZQmsFK7XK6KIU_KeUmJPLmXO_niXp7cy9l9oZtX9H5yY9H3Jvd15qBYODqYZNIOggbjJtBZmuje2PAPSPqkeQ |
| CitedBy_id | crossref_primary_10_1016_j_compbiolchem_2024_108156 crossref_primary_10_3389_fgene_2022_1039465 crossref_primary_10_1016_j_trecan_2022_12_001 |
| Cites_doi | 10.7150/thno.30305 10.1097/MBC.0b013e32830b2891 10.1124/mol.117.110130 10.1183/09031936.02.00290202 10.3390/cells9020457 10.1038/s41598-019-56447-2 10.1080/2162402X.2017.1409929 10.1002/1878-0261.12019 10.1016/j.bbagen.2013.08.020 10.1016/j.cub.2015.09.054 10.1369/0022155412470834 10.12659/MSM.912098 10.30802/AALAS-CM-19-000042 10.1038/s41598-018-20821-3 10.1124/mol.119.118661 10.4161/sgtp.25131 10.1080/2162402X.2016.1259049 10.3390/ijms21124526 10.1002/9780470942390.mo110217 10.1038/ncomms10029 10.3390/ijms20163847 10.1038/srep02932 10.1046/j.1523-1747.2000.00199.x 10.1111/j.1365-2567.2007.02728.x 10.3390/ijms19103028 10.3389/fonc.2019.01370 10.1038/s41598-019-40519-4 10.1002/tox.22764 10.1016/j.etap.2019.03.003 10.1007/s10456-012-9277-x 10.3892/ijo.2017.4100 10.1038/s41598-017-09300-3 10.1126/sciadv.abc4882 10.7150/ijbs.23230 10.1371/journal.pone.0014264 10.1042/BJ20040058 10.1210/en.2010-1166 10.1097/CMR.0000000000000043 10.1042/BC20090060 10.4161/cc.20316 10.1186/s40942-017-0084-9 10.3389/fncel.2015.00280 10.1097/MD.0000000000008488 10.1155/2012/647684 10.3390/ijms20112767 10.1182/blood-2015-10-678706 10.1158/1078-0432.CCR-10-2798 10.3390/cancers12051172 10.1016/j.freeradbiomed.2007.04.027 10.1016/j.febslet.2012.05.010 10.3332/ecancer.2016.617 10.1002/jcp.21935 10.1002/jcb.22997 10.1074/jbc.M116.719518 10.1007/s00005-015-0382-6 10.3389/fphar.2019.00942 10.1007/s10495-017-1407-x 10.21873/cgp.20128 10.1111/cas.13554 10.1111/pcmr.12085 10.1038/35036374 10.18632/oncotarget.15248 10.12688/f1000research.7909.1 10.1186/s13073-020-00780-z 10.21037/tlcr.2016.06.07 10.1111/iep.12192 10.1080/21541248.2017.1341366 10.1021/cb5006323 |
| ContentType | Journal Article |
| Copyright | 2022 Elsevier Inc. Copyright © 2022 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2022 Elsevier Inc. – notice: Copyright © 2022 Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION 7X8 |
| DOI | 10.1016/j.cellsig.2022.110389 |
| DatabaseName | CrossRef MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1873-3913 |
| ExternalDocumentID | 10_1016_j_cellsig_2022_110389 S0898656822001516 |
| GroupedDBID | --- --K --M .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29B 4.4 457 4G. 53G 5GY 5VS 6J9 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K WUQ ZGI ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH 7X8 |
| ID | FETCH-LOGICAL-c342t-be61e124e67b32c39bdccf5fa4f2a0f518da8679b924e0ddcac49e1cbfe7b1fb3 |
| IEDL.DBID | .~1 |
| ISSN | 0898-6568 1873-3913 |
| IngestDate | Fri Jul 11 07:45:04 EDT 2025 Tue Jul 01 03:19:05 EDT 2025 Thu Apr 24 23:11:58 EDT 2025 Fri Feb 23 02:38:55 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | PBS IL ROCK VEGF regulatory axis DMSO JNK VEGF pROCKIISer1366 CDK HMGB1 EDTA MMP9 ECM CBP KD-025 DMEM FAK MMP STAT Metastatic lung melanoma FBS TGFβ Smad complex Smad |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c342t-be61e124e67b32c39bdccf5fa4f2a0f518da8679b924e0ddcac49e1cbfe7b1fb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PQID | 2678746126 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2678746126 crossref_citationtrail_10_1016_j_cellsig_2022_110389 crossref_primary_10_1016_j_cellsig_2022_110389 elsevier_sciencedirect_doi_10_1016_j_cellsig_2022_110389 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | September 2022 2022-09-00 20220901 |
| PublicationDateYYYYMMDD | 2022-09-01 |
| PublicationDate_xml | – month: 09 year: 2022 text: September 2022 |
| PublicationDecade | 2020 |
| PublicationTitle | Cellular signalling |
| PublicationYear | 2022 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Liu, Wada, Katsura (bb0085) 2018; 8 Cirillo, Ghiroldi, Fania (bb0220) 2016; 291 Takezawa, Okamoto (bb0255) 2011; 17 Young, Das, Anowai (bb0045) 2019; 20 Foerster, Boegel, Heck (bb0145) 2018; 7 Singh, Kundu, Ganguly (bb0200) 2007; 43 Sengupta, Chowdhury, Chatterjee (bb0205) 2017; 22 Jerrell, Leih, Parekh (bb0115) 2020; 11 Saman, Raza, Uddin (bb0275) 2020; 12 Zhao, Mishra, Deng (bb0130) 2018; 14 Goebel, Louden, McKenna (bb0025) 2019; 16 Jerrell, Parekh (bb0290) 2015, January; Vol. 26 Lennicke, Rahn, Bukur (bb0135) 2017; 6 O’Connor, Chen (bb0285) 2013; 4 Liang, Li, Zhang (bb0265) 2013; 3 Morgan-Fisher, Wewer, Yoneda (bb0075) 2013; 61 Rodriguez-Hernandez, Cantelli, Bruce (bb0100) 2016; 5 Homan, Larimore, Elkins (bb0295) 2015; 10 Sandru, Voinea, Panaitescu (bb0015) 2014; 7 Pandya, Orgaz, Sanz-Moreno (bb0095) 2017; 11 Arvelo, Sojo, Cotte (bb0060) 2016; 10 Ogawa, Chen, Kuang (bb0120) 2004; 381 Bisceglia, Battistelli, Noce (bb0110) 2019; 10 Kim, Kim, Kong, Bae, Kim, Lee, Lee (bb0355) 2011; 112 Srinivasan, Ashok, Mohanty (bb0325) 2017; 8 Fouad, Aanei (bb0305) 2017; 7 Wei, Surma, Shi (bb0320) 2016; 64 Tas (bb0020) 2012; 2012 Borges, Porto, Teixeira (bb0155) 2010; 5 Bergers, Brekken, McMahon (bb0055) 2000; 2 Wan, Zhu, Zhang, Hou (bb0240) 2018; 17 Fares, Fares, Khachfe (bb0065) 2020; 5 Kim, Peacock, George (bb0230) 2012; 15 Walker, Mojares, del Río Hernández (bb0345) 2018; 19 Barillari (bb0245) 2020; 21 Gong, Zhou, Khelfat (bb0070) 2019; 25 Field, Youngson (bb0335) 2002; 20 Zappa, Mousa (bb0030) 2016; 5 Chowdhury, Sarkar, Chatterjee (bb0215) 2019; 68 Quintero-Fabián, Arreola, Becerril-Villanueva (bb0035) 2019; 9 Xu, Liu, Derynck (bb0125) 2012; 586 Yu, Ye (bb0250) 2020; 9 Yamaguchi, Nakao, Arima (bb0080) 2017; 2017 Uong, Zon (bb0005) 2010; 222 Bouley, Waldschmidt, Cato (bb0165) 2017; 92 Luo, Chen, Li, Lu, Long, Peng, Li (bb0270) 2017; 51 Diep, Hong, Khun (bb0300) 2018; 8 Sengupta, Chowdhury, Sarkar (bb0210) 2014; 1840 Semba, Sugihara, Kamoshita (bb0190) 2018; 109 Cabral, Mello, Lima (bb0350) 2017; 3 Lacal, Failla, Pagani, Odorisio, Schietroma, Falcinelli, D'Atri (bb0365) 2000; 115 Reinhard, Razak, Ethell (bb0050) 2015; 9 Saforo, Omer, Smolenkov (bb0340) 2019; 9 Moreth, Iozzo, Schaefer (bb0040) 2012; 11 Benoit, Lussier, Ducharme (bb0315) 2009; 101 Talkenberger, Cavalcanti-Adam, Voss-Böhme (bb0330) 2017; 7 Flynn, Paz, Du (bb0160) 2016; 127 Oviedo-Orta, Bermudez-Fajardo, Karanam (bb0185) 2008; 124 Hao, Baker, ten Dijke (bb0260) 2019; 20 Cantelli, Orgaz, Rodriguez-Hernandez (bb0105) 2015; 25 Srinivasan, Das, Surve (bb0310) 2019; 9 Shi, Liu, Liu, Geng, Zhou, Chen (bb0360) 2014; 24 Schram, Ganguly, No (bb0090) 2011; 152 Ye, Kuang, Xie, Liang, Zhang, Zhang, Chen (bb0370) 2020; 12 Chatterjee, Patra, Chakraborti (bb0195) 2019; 34 Turner, Pang, Lofgren (bb0175) 2019; 69 Lobos-González, Aguilar, Diaz (bb0140) 2013; 26 Hyun, Seo, Choi, Kwon, Kim, Jeong, Kim (bb5000) 2020; 6 Mihajlovic, Vlajkovic, Jovanovic (bb0010) 2012; 5 Fu, Satterlee, Wang (bb0150) 2016; 97 Truebestein, Elsner, Fuchs (bb0225) 2015; 6 Boerma, Fu, Wang, Loose, Bartolozzi, Ellis, Hauer-Jensen (bb0235) 2008; 19 Chen, Liu, Wang (bb0280) 2017; 96 Burkholder, Foltz, Karlsson, Linton, Smith (bb0180) 2012; 2 Bouley, Weinberg, Waldschmidt (bb0170) 2020; 97 Semba (10.1016/j.cellsig.2022.110389_bb0190) 2018; 109 Saforo (10.1016/j.cellsig.2022.110389_bb0340) 2019; 9 Barillari (10.1016/j.cellsig.2022.110389_bb0245) 2020; 21 Saman (10.1016/j.cellsig.2022.110389_bb0275) 2020; 12 Singh (10.1016/j.cellsig.2022.110389_bb0200) 2007; 43 Hyun (10.1016/j.cellsig.2022.110389_bb5000) 2020; 6 Reinhard (10.1016/j.cellsig.2022.110389_bb0050) 2015; 9 Wan (10.1016/j.cellsig.2022.110389_bb0240) 2018; 17 Morgan-Fisher (10.1016/j.cellsig.2022.110389_bb0075) 2013; 61 Srinivasan (10.1016/j.cellsig.2022.110389_bb0325) 2017; 8 Moreth (10.1016/j.cellsig.2022.110389_bb0040) 2012; 11 Chowdhury (10.1016/j.cellsig.2022.110389_bb0215) 2019; 68 Jerrell (10.1016/j.cellsig.2022.110389_bb0290) 2015; Vol. 26 Benoit (10.1016/j.cellsig.2022.110389_bb0315) 2009; 101 Bouley (10.1016/j.cellsig.2022.110389_bb0170) 2020; 97 Burkholder (10.1016/j.cellsig.2022.110389_bb0180) 2012; 2 Sengupta (10.1016/j.cellsig.2022.110389_bb0205) 2017; 22 Truebestein (10.1016/j.cellsig.2022.110389_bb0225) 2015; 6 Yu (10.1016/j.cellsig.2022.110389_bb0250) 2020; 9 Borges (10.1016/j.cellsig.2022.110389_bb0155) 2010; 5 Zappa (10.1016/j.cellsig.2022.110389_bb0030) 2016; 5 Xu (10.1016/j.cellsig.2022.110389_bb0125) 2012; 586 Wei (10.1016/j.cellsig.2022.110389_bb0320) 2016; 64 Tas (10.1016/j.cellsig.2022.110389_bb0020) 2012; 2012 Schram (10.1016/j.cellsig.2022.110389_bb0090) 2011; 152 Liang (10.1016/j.cellsig.2022.110389_bb0265) 2013; 3 Pandya (10.1016/j.cellsig.2022.110389_bb0095) 2017; 11 Fares (10.1016/j.cellsig.2022.110389_bb0065) 2020; 5 Cabral (10.1016/j.cellsig.2022.110389_bb0350) 2017; 3 Bergers (10.1016/j.cellsig.2022.110389_bb0055) 2000; 2 Yamaguchi (10.1016/j.cellsig.2022.110389_bb0080) 2017; 2017 Arvelo (10.1016/j.cellsig.2022.110389_bb0060) 2016; 10 Gong (10.1016/j.cellsig.2022.110389_bb0070) 2019; 25 Lennicke (10.1016/j.cellsig.2022.110389_bb0135) 2017; 6 Homan (10.1016/j.cellsig.2022.110389_bb0295) 2015; 10 Talkenberger (10.1016/j.cellsig.2022.110389_bb0330) 2017; 7 Cantelli (10.1016/j.cellsig.2022.110389_bb0105) 2015; 25 Takezawa (10.1016/j.cellsig.2022.110389_bb0255) 2011; 17 O’Connor (10.1016/j.cellsig.2022.110389_bb0285) 2013; 4 Walker (10.1016/j.cellsig.2022.110389_bb0345) 2018; 19 Boerma (10.1016/j.cellsig.2022.110389_bb0235) 2008; 19 Shi (10.1016/j.cellsig.2022.110389_bb0360) 2014; 24 Hao (10.1016/j.cellsig.2022.110389_bb0260) 2019; 20 Kim (10.1016/j.cellsig.2022.110389_bb0230) 2012; 15 Sandru (10.1016/j.cellsig.2022.110389_bb0015) 2014; 7 Chen (10.1016/j.cellsig.2022.110389_bb0280) 2017; 96 Sengupta (10.1016/j.cellsig.2022.110389_bb0210) 2014; 1840 Lobos-González (10.1016/j.cellsig.2022.110389_bb0140) 2013; 26 Mihajlovic (10.1016/j.cellsig.2022.110389_bb0010) 2012; 5 Srinivasan (10.1016/j.cellsig.2022.110389_bb0310) 2019; 9 Lacal (10.1016/j.cellsig.2022.110389_bb0365) 2000; 115 Liu (10.1016/j.cellsig.2022.110389_bb0085) 2018; 8 Kim (10.1016/j.cellsig.2022.110389_bb0355) 2011; 112 Bouley (10.1016/j.cellsig.2022.110389_bb0165) 2017; 92 Luo (10.1016/j.cellsig.2022.110389_bb0270) 2017; 51 Fu (10.1016/j.cellsig.2022.110389_bb0150) 2016; 97 Young (10.1016/j.cellsig.2022.110389_bb0045) 2019; 20 Jerrell (10.1016/j.cellsig.2022.110389_bb0115) 2020; 11 Ogawa (10.1016/j.cellsig.2022.110389_bb0120) 2004; 381 Turner (10.1016/j.cellsig.2022.110389_bb0175) 2019; 69 Uong (10.1016/j.cellsig.2022.110389_bb0005) 2010; 222 Diep (10.1016/j.cellsig.2022.110389_bb0300) 2018; 8 Goebel (10.1016/j.cellsig.2022.110389_bb0025) 2019; 16 Rodriguez-Hernandez (10.1016/j.cellsig.2022.110389_bb0100) 2016; 5 Chatterjee (10.1016/j.cellsig.2022.110389_bb0195) 2019; 34 Ye (10.1016/j.cellsig.2022.110389_bb0370) 2020; 12 Flynn (10.1016/j.cellsig.2022.110389_bb0160) 2016; 127 Field (10.1016/j.cellsig.2022.110389_bb0335) 2002; 20 Bisceglia (10.1016/j.cellsig.2022.110389_bb0110) 2019; 10 Cirillo (10.1016/j.cellsig.2022.110389_bb0220) 2016; 291 Fouad (10.1016/j.cellsig.2022.110389_bb0305) 2017; 7 Oviedo-Orta (10.1016/j.cellsig.2022.110389_bb0185) 2008; 124 Quintero-Fabián (10.1016/j.cellsig.2022.110389_bb0035) 2019; 9 Zhao (10.1016/j.cellsig.2022.110389_bb0130) 2018; 14 Foerster (10.1016/j.cellsig.2022.110389_bb0145) 2018; 7 |
| References_xml | – volume: 25 start-page: 3090 year: 2019 end-page: 3099 ident: bb0070 article-title: Rho-associated protein kinase (ROCK) promotes proliferation and migration of PC-3 and DU145 prostate cancer cells by targeting LIM kinase 1 (LIMK1) and matrix metalloproteinase-2 (MMP-2) publication-title: Med. Sci. Monit. – volume: 17 start-page: 2140 year: 2011 end-page: 2148 ident: bb0255 article-title: Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor–induced apoptosis in EML4-ALK–positive lung cancer publication-title: Clin. Cancer Res. – volume: 11 start-page: 131 year: 2020 end-page: 137 ident: bb0115 article-title: The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells publication-title: Small GTPases – volume: 68 start-page: 120 year: 2019 end-page: 132 ident: bb0215 article-title: Cathepsin B mediated scramblase activation triggers cytotoxicity and cell cycle arrest by andrographolide to overcome cellular resistance in cisplatin resistant human hepatocellular carcinoma HepG2 cells publication-title: Environ. Toxicol. Pharmacol. – volume: 10 start-page: 942 year: 2019 ident: bb0110 article-title: TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases publication-title: Front. Pharmacol. – volume: 16 start-page: 229 year: 2019 end-page: 244 ident: bb0025 article-title: Diagnosis of non-small cell lung cancer for early stage asymptomatic patients publication-title: Cancer Genomics-Proteomics – volume: 8 start-page: 21418 year: 2017 end-page: 21428 ident: bb0325 article-title: Blockade of Rho-associated protein kinase (ROCK) inhibits the contractility and invasion potential of cancer stem like cells publication-title: Oncotarget. – volume: 34 start-page: 928 year: 2019 end-page: 940 ident: bb0195 article-title: Association of p38MAPK-p53-Fas aggregation in S-allyl cysteine mediated regulation of hepatocarcinoma publication-title: Environ. Toxicol. – volume: 1840 start-page: 219 year: 2014 end-page: 244 ident: bb0210 article-title: Berberine and S allyl cysteine mediated amelioration of DEN+ CCl4 induced hepatocarcinoma publication-title: Biochim. Biophys. Acta (BBA) – volume: 101 start-page: 695 year: 2009 end-page: 708 ident: bb0315 article-title: Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism publication-title: Biol. Cell. – volume: 381 start-page: 413 year: 2004 end-page: 422 ident: bb0120 article-title: Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-β is mediated by a nuclear factor-κB site publication-title: Biochem. J. – volume: 8 start-page: 1 year: 2018 end-page: 14 ident: bb0300 article-title: Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells publication-title: Sci. Rep. – volume: 26 start-page: 555 year: 2013 end-page: 570 ident: bb0140 article-title: E-cadherin determines C aveolin-1 tumor suppression or metastasis enhancing function in melanoma cells publication-title: Pigment Cell Melanoma Res. – volume: 97 start-page: 351 year: 2016 end-page: 356 ident: bb0150 article-title: Novel murine tumour models depend on strain and route of inoculation publication-title: Int. J. Exp. Pathol. – volume: 5 start-page: 288 year: 2016 end-page: 300 ident: bb0030 article-title: Non-small cell lung cancer: current treatment and future advances publication-title: Transl. Lung Cancer Res. – volume: 11 start-page: 2084 year: 2012 end-page: 2091 ident: bb0040 article-title: Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation publication-title: Cell Cycle – volume: 152 start-page: 2037 year: 2011 end-page: 2047 ident: bb0090 article-title: Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration publication-title: Endocrinology – volume: 12 start-page: 1172 year: 2020 ident: bb0275 article-title: Inducing angiogenesis, a key step in cancer vascularization, and treatment approaches publication-title: Cancers. – volume: 6 year: 2020 ident: bb5000 article-title: Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell–associated lung inflammation publication-title: Sci. Adv. – volume: 43 start-page: 289 year: 2007 end-page: 299 ident: bb0200 article-title: Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer publication-title: Free Radic. Biol. Med. – volume: 9 start-page: 1370 year: 2019 ident: bb0035 article-title: Role of matrix metalloproteinases in angiogenesis and cancer publication-title: Front. Oncol. – volume: 12 start-page: 1 year: 2020 end-page: 19 ident: bb0370 article-title: Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1 publication-title: Genome Med. – volume: 9 start-page: 1 year: 2019 end-page: 16 ident: bb0340 article-title: Primary lung cancer samples cultured under microenvironment-mimetic conditions enrich for mesenchymal stem-like cells that promote metastasis publication-title: Sci. Rep. – volume: 15 start-page: 497 year: 2012 end-page: 509 ident: bb0230 article-title: BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II publication-title: Angiogenesis – volume: 92 start-page: 707 year: 2017 end-page: 717 ident: bb0165 article-title: Structural determinants influencing the potency and selectivity of indazole-paroxetine hybrid G protein–coupled receptor kinase 2 inhibitors publication-title: Mol. Pharmacol. – volume: 112 start-page: 894 year: 2011 end-page: 901 ident: bb0355 article-title: Vitamin C down-regulates VEGF production in B16F10 murine melanoma cells via the suppression of p42/44 MAPK activation publication-title: J. Cell. Biochem. – volume: 2017 start-page: 8543592 year: 2017 ident: bb0080 article-title: Rho-kinase/ROCK as a potential drug target for vitreoretinal diseases publication-title: J. Opt. – volume: 3 start-page: 2932 year: 2013 ident: bb0265 article-title: CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression publication-title: Sci. Rep. – volume: 10 start-page: 310 year: 2015 end-page: 319 ident: bb0295 article-title: Identification and structure–function analysis of subfamily selective g protein-coupled receptor kinase inhibitors publication-title: ACS Chem. Biol. – volume: 8 start-page: 6053 year: 2018 end-page: 6069 ident: bb0085 article-title: Rho-associated coiled-coil kinase (ROCK) in molecular regulation of angiogenesis publication-title: Theranostics. – volume: 19 start-page: 3028 year: 2018 ident: bb0345 article-title: Role of extracellular matrix in development and cancer progression publication-title: Int. J. Mol. Sci. – volume: 7 start-page: 1016 year: 2017 end-page: 1036 ident: bb0305 article-title: Revisiting the hallmarks of cancer publication-title: Am. J. Cancer Res. – volume: 20 start-page: 464 year: 2002 end-page: 479 ident: bb0335 article-title: The Liverpool Lung Project: a molecular epidemiological study of early lung cancer detection publication-title: Eur. Respir. J. – volume: 5 start-page: 1 year: 2020 end-page: 17 ident: bb0065 article-title: Molecular principles of metastasis: a hallmark of cancer revisited publication-title: Signal Transduct. Target. Ther. – volume: 14 start-page: 111 year: 2018 end-page: 123 ident: bb0130 article-title: The role of TGF-β/SMAD4 signaling in cancer publication-title: Int. J. Biol. Sci. – volume: 69 start-page: 451 year: 2019 end-page: 467 ident: bb0175 article-title: A review of pain assessment methods in laboratory rodents publication-title: Compar. Med. – volume: 2 start-page: 737 year: 2000 end-page: 744 ident: bb0055 article-title: Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis publication-title: Nat. Cell Biol. – volume: 20 start-page: 2767 year: 2019 ident: bb0260 article-title: TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis publication-title: Int. J. Mol. Sci. – volume: 9 year: 2019 ident: bb0310 article-title: Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility publication-title: Sci. Rep. – volume: 25 start-page: 2899 year: 2015 end-page: 2914 ident: bb0105 article-title: TGF-β-induced transcription sustains amoeboid melanoma migration and dissemination publication-title: Curr. Biol. – volume: 115 start-page: 1000 year: 2000 end-page: 1007 ident: bb0365 article-title: Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor publication-title: J. Investig. Dermatol. – volume: 20 start-page: 3847 year: 2019 ident: bb0045 article-title: Matrix metalloproteases as influencers of the cells’ social media publication-title: Int. J. Mol. Sci. – volume: 5 year: 2010 ident: bb0155 article-title: Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+ CD25+ regulatory T cells publication-title: PLoS One – volume: 17 start-page: 7351 year: 2018 end-page: 7355 ident: bb0240 article-title: Gefitinib inhibits malignant melanoma cells through the VEGF/AKT signaling pathway publication-title: Mol. Med. Rep. – volume: 4 start-page: 141 year: 2013 end-page: 147 ident: bb0285 article-title: Dynamic functions of RhoA in tumor cell migration and invasion publication-title: Small GTPases – volume: 5 year: 2016 ident: bb0100 article-title: Rho, ROCK and actomyosin contractility in metastasis as drug targets publication-title: F1000Research – volume: 19 start-page: 709 year: 2008 ident: bb0235 article-title: Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of rho kinase or atorvastatin publication-title: Blood coagul. Fibrinolysis – volume: 24 start-page: 99 year: 2014 end-page: 107 ident: bb0360 article-title: β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 publication-title: Melanoma Res. – volume: 222 start-page: 38 year: 2010 end-page: 41 ident: bb0005 article-title: Melanocytes in development and cancer publication-title: J. Cell. Physiol. – volume: 5 start-page: 739 year: 2012 ident: bb0010 article-title: Primary mucosal melanomas: a comprehensive review publication-title: Int. J. Clin. Exp. Pathol. – volume: 96 year: 2017 ident: bb0280 article-title: Quantification of STAT3 and VEGF expression for molecular diagnosis of lymph node metastasis in breast cancer publication-title: Medicine. – volume: 3 start-page: 31 year: 2017 ident: bb0350 article-title: Retinal and choroidal angiogenesis: a review of new targets publication-title: Int. J. Retina Vitreous – volume: 7 start-page: 1 year: 2017 end-page: 12 ident: bb0330 article-title: Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments publication-title: Sci. Rep. – volume: 7 year: 2018 ident: bb0145 article-title: Enhanced protection of C57 BL/6 vs Balb/c mice to melanoma liver metastasis is mediated by NK cells publication-title: Oncoimmunology. – volume: 97 start-page: 392 year: 2020 end-page: 401 ident: bb0170 article-title: A new paroxetine-based GRK2 inhibitor reduces internalization of the μ-opioid receptor publication-title: Mol. Pharmacol. – volume: 21 start-page: 4526 year: 2020 ident: bb0245 article-title: The impact of matrix metalloproteinase-9 on the sequential steps of the metastatic process publication-title: Int. J. Mol. Sci. – volume: Vol. 26 year: 2015, January ident: bb0290 article-title: The ROCK isoforms differentially regulate invadopodia activity to affect invasion but not migration publication-title: Molecular Biology of the Cell – volume: 2 start-page: 145 year: 2012 end-page: 165 ident: bb0180 article-title: Health evaluation of experimental laboratory mice publication-title: Curr. Protocols Mouse Biol. – volume: 22 start-page: 1362 year: 2017 end-page: 1379 ident: bb0205 article-title: Modulation of adenylate cyclase signaling in association with MKK3/6 stabilization under combination of SAC and berberine to reduce HepG2 cell survivability publication-title: Apoptosis. – volume: 109 start-page: 1447 year: 2018 end-page: 1454 ident: bb0190 article-title: Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma publication-title: Cancer Sci. – volume: 6 year: 2017 ident: bb0135 article-title: Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid publication-title: Oncoimmunology. – volume: 6 start-page: 1 year: 2015 end-page: 13 ident: bb0225 article-title: A molecular ruler regulates cytoskeletal remodeling by the rho kinases publication-title: Nat. Commun. – volume: 127 start-page: 2144 year: 2016 end-page: 2154 ident: bb0160 article-title: Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism publication-title: Blood. – volume: 124 start-page: 42 year: 2008 end-page: 50 ident: bb0185 article-title: Comparison of MMP-2 and MMP-9 secretion from T helper 0, 1 and 2 lymphocytes alone and in coculture with macrophages publication-title: Immunology. – volume: 291 start-page: 10615 year: 2016 end-page: 10624 ident: bb0220 article-title: NEU3 sialidase protein interactors in the plasma membrane and in the endosomes publication-title: J. Biol. Chem. – volume: 2012 year: 2012 ident: bb0020 article-title: Metastatic behavior in melanoma: timing, pattern, survival, and influencing factors publication-title: J. Oncol. – volume: 7 start-page: 572 year: 2014 ident: bb0015 article-title: Survival rates of patients with metastatic malignant melanoma publication-title: J. Med. Life – volume: 10 year: 2016 ident: bb0060 article-title: Tumour progression and metastasis publication-title: Ecancermedicalscience – volume: 61 start-page: 185 year: 2013 end-page: 198 ident: bb0075 article-title: Regulation of ROCK activity in cancer publication-title: J. Histochem. Cytochem. – volume: 586 start-page: 1871 year: 2012 end-page: 1884 ident: bb0125 article-title: Post-translational regulation of TGF-β receptor and Smad signaling publication-title: FEBS Lett. – volume: 9 start-page: 457 year: 2020 ident: bb0250 article-title: Role of angiopoietins in development of cancer and neoplasia associated with viral infection publication-title: Cells. – volume: 51 start-page: 1209 year: 2017 end-page: 1218 ident: bb0270 article-title: Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma publication-title: Int. J. Oncol. – volume: 9 start-page: 280 year: 2015 ident: bb0050 article-title: A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders publication-title: Front. Cell. Neurosci. – volume: 11 start-page: 5 year: 2017 end-page: 27 ident: bb0095 article-title: Modes of invasion during tumour dissemination publication-title: Mol. Oncol. – volume: 64 start-page: 259 year: 2016 end-page: 278 ident: bb0320 article-title: Novel insights into the roles of Rho kinase in cancer publication-title: Arch. Immunol. Ther. Exp. – volume: 8 start-page: 6053 issue: 21 year: 2018 ident: 10.1016/j.cellsig.2022.110389_bb0085 article-title: Rho-associated coiled-coil kinase (ROCK) in molecular regulation of angiogenesis publication-title: Theranostics. doi: 10.7150/thno.30305 – volume: 19 start-page: 709 issue: 7 year: 2008 ident: 10.1016/j.cellsig.2022.110389_bb0235 article-title: Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of rho kinase or atorvastatin publication-title: Blood coagul. Fibrinolysis doi: 10.1097/MBC.0b013e32830b2891 – volume: 92 start-page: 707 issue: 6 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0165 article-title: Structural determinants influencing the potency and selectivity of indazole-paroxetine hybrid G protein–coupled receptor kinase 2 inhibitors publication-title: Mol. Pharmacol. doi: 10.1124/mol.117.110130 – volume: 20 start-page: 464 issue: 2 year: 2002 ident: 10.1016/j.cellsig.2022.110389_bb0335 article-title: The Liverpool Lung Project: a molecular epidemiological study of early lung cancer detection publication-title: Eur. Respir. J. doi: 10.1183/09031936.02.00290202 – volume: 2017 start-page: 8543592 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0080 article-title: Rho-kinase/ROCK as a potential drug target for vitreoretinal diseases publication-title: J. Opt. – volume: 9 start-page: 457 issue: 2 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb0250 article-title: Role of angiopoietins in development of cancer and neoplasia associated with viral infection publication-title: Cells. doi: 10.3390/cells9020457 – volume: 9 issue: 1 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0310 article-title: Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility publication-title: Sci. Rep. doi: 10.1038/s41598-019-56447-2 – volume: 7 issue: 4 year: 2018 ident: 10.1016/j.cellsig.2022.110389_bb0145 article-title: Enhanced protection of C57 BL/6 vs Balb/c mice to melanoma liver metastasis is mediated by NK cells publication-title: Oncoimmunology. doi: 10.1080/2162402X.2017.1409929 – volume: 11 start-page: 5 issue: 1 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0095 article-title: Modes of invasion during tumour dissemination publication-title: Mol. Oncol. doi: 10.1002/1878-0261.12019 – volume: 1840 start-page: 219 issue: 1 year: 2014 ident: 10.1016/j.cellsig.2022.110389_bb0210 article-title: Berberine and S allyl cysteine mediated amelioration of DEN+ CCl4 induced hepatocarcinoma publication-title: Biochim. Biophys. Acta (BBA) doi: 10.1016/j.bbagen.2013.08.020 – volume: 25 start-page: 2899 issue: 22 year: 2015 ident: 10.1016/j.cellsig.2022.110389_bb0105 article-title: TGF-β-induced transcription sustains amoeboid melanoma migration and dissemination publication-title: Curr. Biol. doi: 10.1016/j.cub.2015.09.054 – volume: 61 start-page: 185 issue: 3 year: 2013 ident: 10.1016/j.cellsig.2022.110389_bb0075 article-title: Regulation of ROCK activity in cancer publication-title: J. Histochem. Cytochem. doi: 10.1369/0022155412470834 – volume: 25 start-page: 3090 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0070 article-title: Rho-associated protein kinase (ROCK) promotes proliferation and migration of PC-3 and DU145 prostate cancer cells by targeting LIM kinase 1 (LIMK1) and matrix metalloproteinase-2 (MMP-2) publication-title: Med. Sci. Monit. doi: 10.12659/MSM.912098 – volume: 69 start-page: 451 issue: 6 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0175 article-title: A review of pain assessment methods in laboratory rodents publication-title: Compar. Med. doi: 10.30802/AALAS-CM-19-000042 – volume: 8 start-page: 1 issue: 1 year: 2018 ident: 10.1016/j.cellsig.2022.110389_bb0300 article-title: Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells publication-title: Sci. Rep. doi: 10.1038/s41598-018-20821-3 – volume: 97 start-page: 392 issue: 6 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb0170 article-title: A new paroxetine-based GRK2 inhibitor reduces internalization of the μ-opioid receptor publication-title: Mol. Pharmacol. doi: 10.1124/mol.119.118661 – volume: 4 start-page: 141 issue: 3 year: 2013 ident: 10.1016/j.cellsig.2022.110389_bb0285 article-title: Dynamic functions of RhoA in tumor cell migration and invasion publication-title: Small GTPases doi: 10.4161/sgtp.25131 – volume: 6 issue: 6 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0135 article-title: Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid publication-title: Oncoimmunology. doi: 10.1080/2162402X.2016.1259049 – volume: 21 start-page: 4526 issue: 12 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb0245 article-title: The impact of matrix metalloproteinase-9 on the sequential steps of the metastatic process publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21124526 – volume: 2 start-page: 145 issue: 2 year: 2012 ident: 10.1016/j.cellsig.2022.110389_bb0180 article-title: Health evaluation of experimental laboratory mice publication-title: Curr. Protocols Mouse Biol. doi: 10.1002/9780470942390.mo110217 – volume: 6 start-page: 1 issue: 1 year: 2015 ident: 10.1016/j.cellsig.2022.110389_bb0225 article-title: A molecular ruler regulates cytoskeletal remodeling by the rho kinases publication-title: Nat. Commun. doi: 10.1038/ncomms10029 – volume: 20 start-page: 3847 issue: 16 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0045 article-title: Matrix metalloproteases as influencers of the cells’ social media publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20163847 – volume: 3 start-page: 2932 year: 2013 ident: 10.1016/j.cellsig.2022.110389_bb0265 article-title: CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression publication-title: Sci. Rep. doi: 10.1038/srep02932 – volume: 115 start-page: 1000 issue: 6 year: 2000 ident: 10.1016/j.cellsig.2022.110389_bb0365 article-title: Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor publication-title: J. Investig. Dermatol. doi: 10.1046/j.1523-1747.2000.00199.x – volume: 124 start-page: 42 issue: 1 year: 2008 ident: 10.1016/j.cellsig.2022.110389_bb0185 article-title: Comparison of MMP-2 and MMP-9 secretion from T helper 0, 1 and 2 lymphocytes alone and in coculture with macrophages publication-title: Immunology. doi: 10.1111/j.1365-2567.2007.02728.x – volume: 19 start-page: 3028 issue: 10 year: 2018 ident: 10.1016/j.cellsig.2022.110389_bb0345 article-title: Role of extracellular matrix in development and cancer progression publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19103028 – volume: 9 start-page: 1370 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0035 article-title: Role of matrix metalloproteinases in angiogenesis and cancer publication-title: Front. Oncol. doi: 10.3389/fonc.2019.01370 – volume: 9 start-page: 1 issue: 1 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0340 article-title: Primary lung cancer samples cultured under microenvironment-mimetic conditions enrich for mesenchymal stem-like cells that promote metastasis publication-title: Sci. Rep. doi: 10.1038/s41598-019-40519-4 – volume: 34 start-page: 928 issue: 8 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0195 article-title: Association of p38MAPK-p53-Fas aggregation in S-allyl cysteine mediated regulation of hepatocarcinoma publication-title: Environ. Toxicol. doi: 10.1002/tox.22764 – volume: 5 start-page: 739 issue: 8 year: 2012 ident: 10.1016/j.cellsig.2022.110389_bb0010 article-title: Primary mucosal melanomas: a comprehensive review publication-title: Int. J. Clin. Exp. Pathol. – volume: 68 start-page: 120 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0215 article-title: Cathepsin B mediated scramblase activation triggers cytotoxicity and cell cycle arrest by andrographolide to overcome cellular resistance in cisplatin resistant human hepatocellular carcinoma HepG2 cells publication-title: Environ. Toxicol. Pharmacol. doi: 10.1016/j.etap.2019.03.003 – volume: 15 start-page: 497 issue: 3 year: 2012 ident: 10.1016/j.cellsig.2022.110389_bb0230 article-title: BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II publication-title: Angiogenesis doi: 10.1007/s10456-012-9277-x – volume: 51 start-page: 1209 issue: 4 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0270 article-title: Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma publication-title: Int. J. Oncol. doi: 10.3892/ijo.2017.4100 – volume: 7 start-page: 1 issue: 1 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0330 article-title: Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments publication-title: Sci. Rep. doi: 10.1038/s41598-017-09300-3 – volume: 6 issue: 45 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb5000 article-title: Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell–associated lung inflammation publication-title: Sci. Adv. doi: 10.1126/sciadv.abc4882 – volume: 17 start-page: 7351 issue: 5 year: 2018 ident: 10.1016/j.cellsig.2022.110389_bb0240 article-title: Gefitinib inhibits malignant melanoma cells through the VEGF/AKT signaling pathway publication-title: Mol. Med. Rep. – volume: Vol. 26 year: 2015 ident: 10.1016/j.cellsig.2022.110389_bb0290 article-title: The ROCK isoforms differentially regulate invadopodia activity to affect invasion but not migration – volume: 7 start-page: 1016 issue: 5 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0305 article-title: Revisiting the hallmarks of cancer publication-title: Am. J. Cancer Res. – volume: 14 start-page: 111 issue: 2 year: 2018 ident: 10.1016/j.cellsig.2022.110389_bb0130 article-title: The role of TGF-β/SMAD4 signaling in cancer publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.23230 – volume: 5 issue: 12 year: 2010 ident: 10.1016/j.cellsig.2022.110389_bb0155 article-title: Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+ CD25+ regulatory T cells publication-title: PLoS One doi: 10.1371/journal.pone.0014264 – volume: 381 start-page: 413 issue: 2 year: 2004 ident: 10.1016/j.cellsig.2022.110389_bb0120 article-title: Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-β is mediated by a nuclear factor-κB site publication-title: Biochem. J. doi: 10.1042/BJ20040058 – volume: 152 start-page: 2037 issue: 5 year: 2011 ident: 10.1016/j.cellsig.2022.110389_bb0090 article-title: Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration publication-title: Endocrinology doi: 10.1210/en.2010-1166 – volume: 24 start-page: 99 issue: 2 year: 2014 ident: 10.1016/j.cellsig.2022.110389_bb0360 article-title: β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 publication-title: Melanoma Res. doi: 10.1097/CMR.0000000000000043 – volume: 101 start-page: 695 issue: 12 year: 2009 ident: 10.1016/j.cellsig.2022.110389_bb0315 article-title: Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism publication-title: Biol. Cell. doi: 10.1042/BC20090060 – volume: 11 start-page: 2084 issue: 11 year: 2012 ident: 10.1016/j.cellsig.2022.110389_bb0040 article-title: Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation publication-title: Cell Cycle doi: 10.4161/cc.20316 – volume: 3 start-page: 31 issue: 1 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0350 article-title: Retinal and choroidal angiogenesis: a review of new targets publication-title: Int. J. Retina Vitreous doi: 10.1186/s40942-017-0084-9 – volume: 9 start-page: 280 year: 2015 ident: 10.1016/j.cellsig.2022.110389_bb0050 article-title: A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2015.00280 – volume: 96 issue: 45 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0280 article-title: Quantification of STAT3 and VEGF expression for molecular diagnosis of lymph node metastasis in breast cancer publication-title: Medicine. doi: 10.1097/MD.0000000000008488 – volume: 2012 year: 2012 ident: 10.1016/j.cellsig.2022.110389_bb0020 article-title: Metastatic behavior in melanoma: timing, pattern, survival, and influencing factors publication-title: J. Oncol. doi: 10.1155/2012/647684 – volume: 20 start-page: 2767 issue: 11 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0260 article-title: TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20112767 – volume: 127 start-page: 2144 issue: 17 year: 2016 ident: 10.1016/j.cellsig.2022.110389_bb0160 article-title: Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism publication-title: Blood. doi: 10.1182/blood-2015-10-678706 – volume: 17 start-page: 2140 issue: 8 year: 2011 ident: 10.1016/j.cellsig.2022.110389_bb0255 article-title: Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor–induced apoptosis in EML4-ALK–positive lung cancer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-10-2798 – volume: 12 start-page: 1172 issue: 5 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb0275 article-title: Inducing angiogenesis, a key step in cancer vascularization, and treatment approaches publication-title: Cancers. doi: 10.3390/cancers12051172 – volume: 43 start-page: 289 issue: 2 year: 2007 ident: 10.1016/j.cellsig.2022.110389_bb0200 article-title: Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2007.04.027 – volume: 586 start-page: 1871 issue: 14 year: 2012 ident: 10.1016/j.cellsig.2022.110389_bb0125 article-title: Post-translational regulation of TGF-β receptor and Smad signaling publication-title: FEBS Lett. doi: 10.1016/j.febslet.2012.05.010 – volume: 10 year: 2016 ident: 10.1016/j.cellsig.2022.110389_bb0060 article-title: Tumour progression and metastasis publication-title: Ecancermedicalscience doi: 10.3332/ecancer.2016.617 – volume: 222 start-page: 38 issue: 1 year: 2010 ident: 10.1016/j.cellsig.2022.110389_bb0005 article-title: Melanocytes in development and cancer publication-title: J. Cell. Physiol. doi: 10.1002/jcp.21935 – volume: 5 start-page: 1 issue: 1 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb0065 article-title: Molecular principles of metastasis: a hallmark of cancer revisited publication-title: Signal Transduct. Target. Ther. – volume: 112 start-page: 894 issue: 3 year: 2011 ident: 10.1016/j.cellsig.2022.110389_bb0355 article-title: Vitamin C down-regulates VEGF production in B16F10 murine melanoma cells via the suppression of p42/44 MAPK activation publication-title: J. Cell. Biochem. doi: 10.1002/jcb.22997 – volume: 291 start-page: 10615 issue: 20 year: 2016 ident: 10.1016/j.cellsig.2022.110389_bb0220 article-title: NEU3 sialidase protein interactors in the plasma membrane and in the endosomes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M116.719518 – volume: 64 start-page: 259 issue: 4 year: 2016 ident: 10.1016/j.cellsig.2022.110389_bb0320 article-title: Novel insights into the roles of Rho kinase in cancer publication-title: Arch. Immunol. Ther. Exp. doi: 10.1007/s00005-015-0382-6 – volume: 10 start-page: 942 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0110 article-title: TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases publication-title: Front. Pharmacol. doi: 10.3389/fphar.2019.00942 – volume: 22 start-page: 1362 issue: 11 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0205 article-title: Modulation of adenylate cyclase signaling in association with MKK3/6 stabilization under combination of SAC and berberine to reduce HepG2 cell survivability publication-title: Apoptosis. doi: 10.1007/s10495-017-1407-x – volume: 7 start-page: 572 issue: 4 year: 2014 ident: 10.1016/j.cellsig.2022.110389_bb0015 article-title: Survival rates of patients with metastatic malignant melanoma publication-title: J. Med. Life – volume: 16 start-page: 229 issue: 4 year: 2019 ident: 10.1016/j.cellsig.2022.110389_bb0025 article-title: Diagnosis of non-small cell lung cancer for early stage asymptomatic patients publication-title: Cancer Genomics-Proteomics doi: 10.21873/cgp.20128 – volume: 109 start-page: 1447 issue: 5 year: 2018 ident: 10.1016/j.cellsig.2022.110389_bb0190 article-title: Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma publication-title: Cancer Sci. doi: 10.1111/cas.13554 – volume: 26 start-page: 555 issue: 4 year: 2013 ident: 10.1016/j.cellsig.2022.110389_bb0140 article-title: E-cadherin determines C aveolin-1 tumor suppression or metastasis enhancing function in melanoma cells publication-title: Pigment Cell Melanoma Res. doi: 10.1111/pcmr.12085 – volume: 2 start-page: 737 issue: 10 year: 2000 ident: 10.1016/j.cellsig.2022.110389_bb0055 article-title: Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis publication-title: Nat. Cell Biol. doi: 10.1038/35036374 – volume: 8 start-page: 21418 issue: 13 year: 2017 ident: 10.1016/j.cellsig.2022.110389_bb0325 article-title: Blockade of Rho-associated protein kinase (ROCK) inhibits the contractility and invasion potential of cancer stem like cells publication-title: Oncotarget. doi: 10.18632/oncotarget.15248 – volume: 5 year: 2016 ident: 10.1016/j.cellsig.2022.110389_bb0100 article-title: Rho, ROCK and actomyosin contractility in metastasis as drug targets publication-title: F1000Research doi: 10.12688/f1000research.7909.1 – volume: 12 start-page: 1 issue: 1 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb0370 article-title: Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1 publication-title: Genome Med. doi: 10.1186/s13073-020-00780-z – volume: 5 start-page: 288 issue: 3 year: 2016 ident: 10.1016/j.cellsig.2022.110389_bb0030 article-title: Non-small cell lung cancer: current treatment and future advances publication-title: Transl. Lung Cancer Res. doi: 10.21037/tlcr.2016.06.07 – volume: 97 start-page: 351 issue: 4 year: 2016 ident: 10.1016/j.cellsig.2022.110389_bb0150 article-title: Novel murine tumour models depend on strain and route of inoculation publication-title: Int. J. Exp. Pathol. doi: 10.1111/iep.12192 – volume: 11 start-page: 131 issue: 2 year: 2020 ident: 10.1016/j.cellsig.2022.110389_bb0115 article-title: The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells publication-title: Small GTPases doi: 10.1080/21541248.2017.1341366 – volume: 10 start-page: 310 issue: 1 year: 2015 ident: 10.1016/j.cellsig.2022.110389_bb0295 article-title: Identification and structure–function analysis of subfamily selective g protein-coupled receptor kinase inhibitors publication-title: ACS Chem. Biol. doi: 10.1021/cb5006323 |
| SSID | ssj0015062 |
| Score | 2.4123726 |
| Snippet | Rho-associated coiled-coil kinase (ROCK) inhibition decreases tumourogenic growth, proliferation and angiogenesis. Multifaceted evidences are there about the... |
| SourceID | proquest crossref elsevier |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 110389 |
| SubjectTerms | KD-025 Metastatic lung melanoma MMP9 pROCKIISer1366 Smad complex VEGF regulatory axis |
| Title | Activity of ROCKII not ROCKI promotes pulmonary metastasis of melanoma cells via modulating Smad2/3-MMP9 and FAK-Src-VEGF signalling |
| URI | https://dx.doi.org/10.1016/j.cellsig.2022.110389 https://www.proquest.com/docview/2678746126 |
| Volume | 97 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhodBLSdKW5okKvWq9luTXcVmy2c2StHSbkpvQMzis7WXtDeSSU354JNlOaCkEejG20RihGc83Y3-aAeDbUNkkmSiCcJzGiBp74CZTKORKGyJpkirP8r2Kp9f04ia62QLjfi-Mo1V2vr_16d5bd3eCbjWDVZ4Hi2GapTYasQjngD90ZbcpTZyVDx5faB6ugJ7_k2AHIzf6dRdPcDdwH8fr_NamiRg7Qjxx3d7_jU9_eWoPP5Nd8KGLG-Gondoe2NLlPnjXdpJ8-AieRrJtAwErA39-H89nM1hWTXsKV55zp2u42iyt2fH1Ayx0w21gWOe1kyj0kpdVwaGfKrzPOSwq5Tt7lbdwUXCFA4IuL39kkJcKTkZztFhL9PvsfAIdA4T7yt6fwPXk7Nd4iroGC0gSihskdBxqC_A6TgTBkmRCSWkiw6nBfGiiMFXcFeQTNknTQ6UklzTToRRGJyI0gnwG22VV6i8AZhGmUaZlLGwMqCzIJVKkQhIccl_79gDQflmZ7KqPuyYYS9bTzO5Ypw3mtMFabRyAwYvYqi2_8ZZA2uuM_WFHzELEW6Jfex0z-465EbzU1aZm2CJ6Qm0sGB_-_-OPwHt31fLTjsF2s97oExvQNOLUW-wp2BnN5tOrZ0kg9YM |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZdytheyq6s6y4a7FW1Lcm3xxCaJUuTjaUdfRO6FpfYDrEz6Pt--CTZ7tgYFPZijK1jhI58viP70_kA-Bgqu0gmiiCcZAmixh64yRWKuNKGSJpmyrN8V8nskn6-iq8OwGTYC-NolX3s72K6j9b9laAfzWBbFME6zPLMZiMW4RzwR8kDcOiqU8UjcDieL2aru58Jceh1RV175Ax-b-QJbk7d9_GmuLYrRYwdJ544wfd_Q9Rfwdoj0PQJOOpTRzjuevcUHOjqGXjYiUnePgc_x7JTgoC1gd--TBbzOazqtjuFW0-70w3c7jd25vHdLSx1y21u2BSNsyj1hld1yaHvKvxRcFjWyot7VddwXXKFA4KWy6855JWC0_ECrXcSfT_7NIWOBMJ9ce8X4HJ6djGZoV5jAUlCcYuETiJtMV4nqSBYklwoKU1sODWYhyaOMsVdTT5h12k6VEpySXMdSWF0KiIjyEswqupKvwIwjzGNcy0TYdNAZXEulSITkuCI-_K3x4AOw8pkX4Dc6WBs2MA0u2G9N5jzBuu8cQxO78y2XQWO-wyywWfsj6nELErcZ_ph8DGzr5lrwStd7xuGLain1KaDyev_f_x78Gh2sTxn5_PV4gQ8dnc6utobMGp3e_3W5jeteNfP31-x2_g0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Activity+of+ROCKII+not+ROCKI+promotes+pulmonary+metastasis+of+melanoma+cells+via+modulating+Smad2%2F3-MMP9+and+FAK-Src-VEGF+signalling&rft.jtitle=Cellular+signalling&rft.au=Chatterjee%2C+Sujan&rft.au=Patra%2C+Debajyoti&rft.au=Ghosh%2C+Pujita&rft.au=Banerjee%2C+Soumi&rft.date=2022-09-01&rft.issn=0898-6568&rft.volume=97&rft.spage=110389&rft_id=info:doi/10.1016%2Fj.cellsig.2022.110389&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_cellsig_2022_110389 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0898-6568&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0898-6568&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0898-6568&client=summon |