Structural analysis of a soluble polysaccharide GSPA-0.3 from the root of Panax ginseng C. A. Meyer and its adjuvant activity with mechanism investigation

• Published in: Carbohydrate polymers Vol. 326; p. 121591
• Main Authors: Feng, Lei, Han, Na, Han, Yu-Bo, Shang, Meng-Wen, Liang, Teng-Wei, Liu, Zhi-Hui, Li, Si-Kai, Zhai, Jian-Xiu, Yin, Jun
• Format: Journal Article
• Language: English
• Published: England 15.02.2024
• Subjects: adjuvants; alum; aluminum; arabinose; galactose; galacturonic acid; GATA transcription factors; glucose; immunoglobulin G; interleukin-4; mannose; mice; molecular weight; Panax ginseng; polysaccharides; rhamnose; splenocytes; vaccines; xylose; H1N1 influenza vaccine; Panax ginseng C. A. Meyer; Adjuvant activity; Polysaccharide

A novel polysaccharide (GSPA-0.3) was isolated and purified from the root of cultivated Panax ginseng C. A. Meyer, and its structure, adjuvant activities, and mechanisms for inducing the maturation of mouse dendritic 2.4 cells (DC2.4) were extensively studied. Fraction GSPA-0.3, mainly composed by t...