African lineage 1a West Nile virus isolated from crocodiles exhibits low neuroinvasiveness in mice

• Published in: Journal of general virology Vol. 105; no. 11
• Main Authors: Kobayashi, Hiroko, Chambaro, Herman, Tabata, Koshiro, Ariizumi, Takuma, Phongphaew, Wallaya, Ndashe, Kunda, Ndebe, Joseph, Fandamu, Paul, Kobayashi, Shintaro, Ito, Naoto, Sasaki, Michihito, Hang'ombe, Bernard M, Simulundu, Edgar, Orba, Yasuko, Sawa, Hirofumi
• Format: Journal Article
• Language: English
• Published: England 26.11.2024
• Subjects: Alligators and Crocodiles - virology; Animals; Chlorocebus aethiops; Female; Mice; Mice, Inbred C57BL; Vero Cells; Virulence; West Nile Fever - virology; West Nile virus - genetics; West Nile virus - isolation & purification; West Nile virus - pathogenicity; Zambia; Zambia; pathogenicity in mice; virus isolation; crocodile; West Nile virus; flavivirus

West Nile virus (WNV) is a mosquito-borne flavivirus that causes encephalitis in humans and infects crocodiles, resulting in rashes and neurological signs. In Zambia, two distinct lineages of WNV have been detected in neighbouring areas: lineage 2 in mosquitoes and lineage 1a in farmed crocodiles. C...