Pharmacokinetic and behavioural profile of THC, CBD, and THC+CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC

• Published in: European neuropsychopharmacology Vol. 27; no. 12; pp. 1223 - 1237
• Main Authors: Hložek, Tomáš, Uttl, Libor, Kadeřábek, Lukáš, Balíková, Marie, Lhotková, Eva, Horsley, Rachel R., Nováková, Pavlína, Šíchová, Klára, Štefková, Kristýna, Tylš, Filip, Kuchař, Martin, Páleníček, Tomáš
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2017
• Subjects: Behaviour; Cannabidiol (CBD); CBD to THC conversion; Pharmacokinetics; Δ9-tetrahydrocannabinol (THC); CBD to THC conversion; Behaviour; Pharmacokinetics; Cannabidiol (CBD); Δ9-tetrahydrocannabinol (THC); Δ-tetrahydrocannabinol (THC)

Metabolic and behavioural effects of, and interactions between Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are influenced by dose and administration route. Therefore we investigated, in Wistar rats, effects of pulmonary, oral and subcutaneous (sc.) THC, CBD and THC+CBD. Concentrations of THC...