The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects
The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200-280 mg dL −1 ) were randomly divided i...
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| Published in | Food & function Vol. 1; no. 5; pp. 2888 - 2893 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
22.05.2019
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| Abstract | The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200-280 mg dL
−1
) were randomly divided into nattokinase and placebo groups (
n
= 50, respectively). No significant between-group differences were found at baseline in collagen-epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT (
P
= 0.001) and aPTT (
P
= 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group (
P
= 0.001). Additionally, a significant correlation between PT and aPTT was observed (
r
= 0.491,
P
< 0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects.
For 8 weeks, individuals who consumed nattokinase, considered one of the most active functional ingredients found in natto, showed improved hemostatic factors. |
|---|---|
| AbstractList | The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200-280 mg dL-1) were randomly divided into nattokinase and placebo groups (n = 50, respectively). No significant between-group differences were found at baseline in collagen-epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT (P = 0.001) and aPTT (P = 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group (P = 0.001). Additionally, a significant correlation between PT and aPTT was observed (r = 0.491, P < 0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects. The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200-280 mg dL −1 ) were randomly divided into nattokinase and placebo groups ( n = 50, respectively). No significant between-group differences were found at baseline in collagen-epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT ( P = 0.001) and aPTT ( P = 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group ( P = 0.001). Additionally, a significant correlation between PT and aPTT was observed ( r = 0.491, P < 0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects. For 8 weeks, individuals who consumed nattokinase, considered one of the most active functional ingredients found in natto, showed improved hemostatic factors. The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200-280 mg dL-1) were randomly divided into nattokinase and placebo groups (n = 50, respectively). No significant between-group differences were found at baseline in collagen-epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT (P = 0.001) and aPTT (P = 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group (P = 0.001). Additionally, a significant correlation between PT and aPTT was observed (r = 0.491, P < 0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects.The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200-280 mg dL-1) were randomly divided into nattokinase and placebo groups (n = 50, respectively). No significant between-group differences were found at baseline in collagen-epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT (P = 0.001) and aPTT (P = 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group (P = 0.001). Additionally, a significant correlation between PT and aPTT was observed (r = 0.491, P < 0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects. The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200–280 mg dL⁻¹) were randomly divided into nattokinase and placebo groups (n = 50, respectively). No significant between-group differences were found at baseline in collagen–epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT (P = 0.001) and aPTT (P = 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group (P = 0.001). Additionally, a significant correlation between PT and aPTT was observed (r = 0.491, P < 0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects. The aim of this study was to investigate whether supplementation with nattokinase, which is considered one of the most active functional ingredients found in natto, alters hemostatic factors. Subjects presenting with hypercholesterolemia (serum cholesterol: 200–280 mg dL −1 ) were randomly divided into nattokinase and placebo groups ( n = 50, respectively). No significant between-group differences were found at baseline in collagen–epinephrine closure time (C-EPI CT), prothrombin time (PT), or activated partial thromboplastin time (aPTT). After 8 weeks of treatment, the nattokinase group exhibited significant increases in C-EPI CT, PT, and aPTT. The nattokinase group showed significantly greater increases in C-EPI CT ( P = 0.001) and aPTT ( P = 0.016) than the placebo group. Moreover, at 8 weeks, the nattokinase group showed a significantly higher C-EPI CT than the placebo group ( P = 0.001). Additionally, a significant correlation between PT and aPTT was observed ( r = 0.491, P < 0.001). In conclusion, nattokinase supplementation was associated with prolonged C-EPI CT and aPTT in nondiabetic and borderline-to-moderate hypercholesterolemic subjects. |
| Author | Yoo, Hye Jin Kim, Minjoo Kim, Minkyung Lee, Ayoung Kim, Tae Su Lee, Jong Ho Lee, Sang-Hyun Jin, Chunmei Lee, Sung Pyo |
| AuthorAffiliation | Research Center for Silver Science Institute of Symbiotic Life-TECH Department of Food and Nutrition Brain Korea 21 PLUS Project National Health Insurance Corporation Ilsan Hospital National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics College of Human Ecology Yonsei University Anydoctor Healthcare Co Ltd Department of Family Practice |
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| Author_xml | – sequence: 1 givenname: Hye Jin surname: Yoo fullname: Yoo, Hye Jin – sequence: 2 givenname: Minkyung surname: Kim fullname: Kim, Minkyung – sequence: 3 givenname: Minjoo surname: Kim fullname: Kim, Minjoo – sequence: 4 givenname: Ayoung surname: Lee fullname: Lee, Ayoung – sequence: 5 givenname: Chunmei surname: Jin fullname: Jin, Chunmei – sequence: 6 givenname: Sung Pyo surname: Lee fullname: Lee, Sung Pyo – sequence: 7 givenname: Tae Su surname: Kim fullname: Kim, Tae Su – sequence: 8 givenname: Sang-Hyun surname: Lee fullname: Lee, Sang-Hyun – sequence: 9 givenname: Jong Ho surname: Lee fullname: Lee, Jong Ho |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31070609$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.amjmed.2007.10.025 10.1016/j.jff.2016.02.026 10.1074/jbc.M101751200 10.1159/000360360 10.1007/s00253-014-6135-3 10.1016/j.htct.2018.05.002 10.1155/2011/742719 10.1007/BF01956052 10.1248/bpb.18.1387 10.1016/j.nutres.2009.01.009 10.2146/ajhp050509 10.1111/j.1538-7836.2007.02366.x 10.3390/ijms18030523 10.1006/bbrc.1993.2624 10.1159/000205051 10.1093/labmed/lmx050 10.5625/lar.2013.29.4.221 10.1007/s11515-017-1453-3 10.1371/journal.pone.0016470 10.1080/03639040601050247 10.3343/alm.2019.39.3.330 10.1161/01.CIR.0000038419.53000.D6 10.1038/srep11601 10.1007/s12010-012-9894-2 10.1093/oxfordjournals.aje.a116211 |
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| SubjectTerms | blood serum cholesterol enzymes functional foods hypercholesterolemia natto placebos prothrombin thromboplastin |
| Title | The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects |
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