Platelet size distribution measurements as indicators of shear stress-induced platelet aggregation

• Published in: Annals of biomedical engineering Vol. 22; no. 6; p. 653
• Main Authors: Slack, S M, Jennings, L K, Turitto, V T
• Format: Journal Article
• Language: English
• Published: United States 01.11.1994
• Subjects: Antibodies, Monoclonal; Blood Platelets - cytology; Blood Platelets - metabolism; Cell Size; Glycoproteins - metabolism; Humans; Integrins - metabolism; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Cytoadhesin - metabolism; Receptors, Vitronectin; Rheology; Stress, Mechanical; Vitronectin; von Willebrand Factor - metabolism

The mechanisms underlying shear stress-induced platelet aggregation (SIPA) were investigated by measuring changes in the platelet size distributions resulting from the exposure of human platelet-rich plasma (PRP) to well-defined shear stresses in a modified viscometer. Exposure of PRP to a shear str...