Immunomodulating action of the 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3′,4′-methylenedioxyphenyl]-coumarin in neutrophils from patients with rheumatoid arthritis and in rats with acute joint inflammation

• Published in: Inflammation research Vol. 69; no. 1; pp. 115 - 130
• Main Authors: Albiero, Lucinéia Reuse, de Andrade, Micássio Fernandes, Marchi, Larissa Fávaro, Landi-Librandi, Ana Paula, de Figueiredo-Rinhel, Andréa Silva Garcia, Carvalho, Camila Andressa, Kabeya, Luciana Mariko, de Oliveira, Renê Donizeti Ribeiro, Azzolini, Ana Elisa Caleiro Seixas, Pupo, Mônica Tallarico, da Silva Emery, Flávio, Lucisano-Valim, Yara Maria
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2020; Springer Nature B.V
• Subjects: Allergology; Antigen-antibody complexes; Arthritis; Biomedical and Life Sciences; Biomedicine; Cell activation; Chemotaxis; Cholesterol; Coumarin; Cytotoxicity; Dermatology; Edema; Elastase; IL-1β; Immunology; Immunomodulators; Infiltration; Inflammation; Interleukin 6; Joints (anatomy); Lecithin; Leukocytes; Leukocytes (neutrophilic); Liposomes; Neurology; Neutrophils; Original Research Paper; Pharmacology/Toxicology; Phosphatidylcholine; Polydispersity; Reactive oxygen species; Remission; Rheumatoid arthritis; Rheumatology; Toxicity; Tumor necrosis factor-α; Zeta potential; Liposome; Inflammation; Neutrophil; Chemotaxis; Rheumatoid arthritis; 3-Phenylcoumarin

Objective To examine whether free (3-PD-5 free ) and/or liposomal (3-PD-5 lipo ) 6,7-dihydroxy-3-[3′,4′-methylenedioxyphenyl]-coumarin (3-PD-5) (1) modulate the effector functions of neutrophils from patients with rheumatoid arthritis under remission (i-RA) and with active disease (a-RA), in vitro;...