Quantitative peripheral live single T-cell dynamic polyfunctionality profiling predicts lung cancer checkpoint immunotherapy treatment response and clinical outcomes

• Published in: Translational lung cancer research Vol. 13; no. 12; pp. 3323 - 3343
• Main Authors: Lim, Zuan-Fu, Wu, Xiaoliang, Zhu, Lin, Albandar, Heidar, Hafez, Maria, Zhao, Chenchen, Almubarak, Mohammed, Smolkin, Matthew, Zheng, Hong, Wen, Sijin, Ma, Patrick C.
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 31.12.2024
• Subjects: Original; predictive biomarkers; polyfunctionality; Cancer immunotherapy; single cell analysis; immune cytokine profiling

Predictive biomarkers for immune checkpoint inhibitors (ICIs), e.g., programmed death ligand-1 (PD-L1) tumor proportional score (TPS), remain limited in clinical applications. Predictive biomarkers that require invasive tumor biopsy procedures are practically challenging especially when longitudinal...