Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine - van Gaalen, Marcel M; Schlumbohm, Christina; Folgering, Joost H; Adhikari, Saugat; Bhattacharya, Chandrali; Steinbach, Douglas; Stratford, Robert E (The Journal of pharmacology and experimental therapeutics, 2019)
Keywords: Animals; Dextroamphetamine - adverse effects; Dextroamphetamine - pharmacokinetics; Dextroamphetamine - pharmacology; Dopamine - metabolism; Kinetics; Macaca fascicularis; Male; Neostriatum - drug effects; Neostriatum - metabolism; Rats; Safety; BBB; D2R; CNS; ECF; PKC; MS/MS; PFC; PD; DAT; CSF; NHP; AIC; PK