Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins

• Published in: International journal of pharmaceutics Vol. 608; p. 121075
• Main Authors: Subasic, Christopher N., Ardana, Aditya, Chan, Linda J., Huang, Fei, Scoble, Judith A., Butcher, Neville J., Meagher, Laurence, Chiefari, John, Kaminskas, Lisa M., Williams, Charlotte C.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.10.2021
• Subjects: PEG; Pharmacokinetics; Polymer pharmacokinetics; Polymers; Reversible Addition-Fragmentation chain-Transfer (RAFT); Ð; Mn; MWCO; PEG; Polymer pharmacokinetics; Mw; Polymers; Pharmacokinetics; Reversible Addition-Fragmentation chain-Transfer (RAFT)

[Display omitted] PEGylation is the standard approach for prolonging the plasma exposure of protein therapeutics but has limitations. We explored whether polymers prepared by Reversible Addition-Fragmentation chain-Transfer (RAFT) may provide better alternatives to polyethylene glycol (PEG). Four RA...