Expression and Dendritic Trafficking of BDNF-6 Splice Variant are Impaired in Knock-In Mice Carrying Human BDNF Val66Met Polymorphism

• Published in: The international journal of neuropsychopharmacology Vol. 18; no. 12; p. pyv069
• Main Authors: Mallei, Alessandra, Baj, Gabriele, Ieraci, Alessandro, Corna, Stefano, Musazzi, Laura, Lee, Francis S., Tongiorgi, Enrico, Popoli, Maurizio
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.11.2015
• Subjects: Animals; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Chromatin Immunoprecipitation; Dendrites - drug effects; Dendrites - metabolism; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Profiling; Gene Knock-In Techniques; Humans; In Situ Hybridization; Jumonji Domain-Containing Histone Demethylases - metabolism; Male; Mice, Transgenic; Muscarinic Agonists - pharmacology; Pilocarpine - pharmacology; Polycomb Repressive Complex 2 - metabolism; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic; Protein Isoforms; Protein Transport - drug effects; Val66Met polymorphism; histone; BDNF; dendritic trafficking; epigenetics

Background: The human Val66Met polymorphism in brain-derived neurotrophic factor (BDNF), a key factor in neuroplasticity, synaptic function, and cognition, has been implicated in the pathophysiology of neuropsychiatric and neurodegenerative disorders. BDNF is encoded by multiple transcripts with dis...