Polymorphism L26V in the Cathepsin B Gene may be Associated with a Risk of Prostate Cancer and Differentiation

• Published in: Journal of international medical research Vol. 37; no. 5; pp. 1604 - 1610
• Main Authors: Štiblar-Martinčič, D, Hajdinjak, T
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.09.2009
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cathepsin B - genetics; Cell Differentiation; DNA - genetics; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Prognosis; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Risk Factors; Slovenia; Young Adult; Slovenia; Prostate adenocarcinoma (PCa); Single nuceotide Polymorphism; Genetic disease predisposition; Cysteine endopeptidases

Cathepsin B is a lysosomal enzyme thought to be involved in tumour cell invasion and metastasis. This study was designed to investigate the presence of a known leucine to valine mutation at position 26 (L26V) single nucleotide polymorphism (SNP) in the cathepsin B (CTSB) gene in a Slovenian Caucasia...