First Time View on Human Metabolome Changes after a Single Intake of 3,4-Methylenedioxymethamphetamine in Healthy Placebo-Controlled Subjects

• Published in: Journal of proteome research Vol. 16; no. 9; pp. 3310 - 3320
• Main Authors: Boxler, Martina I., Liechti, Matthias E., Schmid, Yasmin, Kraemer, Thomas, Steuer, Andrea E.
• Format: Journal Article
• Language: English
• Published: United States 01.09.2017
• Subjects: Adult; adults; biomarkers; Chromatography, High Pressure Liquid - methods; Cross-Over Studies; dose response; Double-Blind Method; drugs; energy; Female; Glycerophospholipids - blood; Hallucinogens - administration & dosage; Hallucinogens - blood; Healthy Volunteers; Humans; Male; metabolites; Metabolome; metabolomics; methionine; Methionine - analogs & derivatives; Methionine - blood; N-Methyl-3,4-methylenedioxyamphetamine - administration & dosage; N-Methyl-3,4-methylenedioxyamphetamine - blood; Oxidative Stress; Placebos; proteome; time series analysis; toxicity; targeted metabolomics; 3,4-methylenedioxymethamphetamine (MDMA); placebo-controlled; methionine; biocrates; ecstasy
• ISSN: 1535-3893; 1535-3907; 1535-3907
• DOI: 10.1021/acs.jproteome.7b00294

3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is widely consumed recreationally. Little is known about its effects on the human metabolome. Mapping biochemical changes after drug exposure can complement traditional approaches by revealing potential biomarkers of organ toxicity or dis...