Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2 , AR , SP140 Methylation and Clinical Phenotype

• Published in: Sleep (New York, N.Y.) Vol. 39; no. 4; pp. 743 - 755
• Main Authors: Chen, Yung-Che, Chen, Ting-Wen, Su, Mao-Chang, Chen, Chung-Jen, Chen, Kuang-Den, Liou, Chia-Wei, Tang, Petrus, Wang, Ting-Ya, Chang, Jen-Chieh, Wang, Chin-Chou, Lin, Hsin-Ching, Chin, Chien-Hung, Huang, Kuo-Tung, Lin, Meng-Chih, Hsiao, Chang-Chun
• Format: Journal Article
• Language: English
• Published: United States Associated Professional Sleep Societies, LLC 01.04.2016
• Subjects: Adult; Aged; Antigens, Nuclear - genetics; Case-Control Studies; Cohort Studies; CpG Islands - genetics; DNA Methylation; Female; Genome, Human - genetics; Genomics; Humans; Hypertension - complications; Hypertension - genetics; Male; Middle Aged; Oxygen - metabolism; Phenotype; Polysomnography; Promoter Regions, Genetic - genetics; Receptors, Androgen - genetics; Receptors, Atrial Natriuretic Factor - genetics; Receptors, Interleukin-1 Type II - genetics; Reproducibility of Results; Sleep Apnea Syndromes - genetics; Sleep Apnea, Obstructive - complications; Sleep Apnea, Obstructive - genetics; Sleep Apnea, Obstructive - physiopathology; Sleep Disordered Breathing; Sleep Stages - genetics; Snoring - complications; Snoring - genetics; Transcription Factors - genetics; Young Adult; obstructive sleep apnea; AR; IL1R2; NPR2; SP140; DNA methylation; excessive daytime sleepiness; oxygen desaturation index

We hypothesized that DNA methylation patterns may contribute to disease severity or the development of hypertension and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA). Illumina's (San Diego, CA, USA) DNA methylation 27-K assay was used to identify differential...