An upstream deletion polymorphism within the goat Period circadian regulator 1 (PER1) gene was associated with growth traits

• Published in: Animal biotechnology Vol. 34; no. 4; pp. 819 - 824
• Main Authors: Zhang, Taiyuan, Liu, Modian, Yang, Yuta, Wang, Ke, Zhao, Haiyu, Pan, Chuanying
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.11.2023; Taylor & Francis Ltd
• Subjects: Animal husbandry; Animals; Body height; Body length; Bone mass; Cashmere; circadian genes; Circadian rhythms; Gene deletion; Gene polymorphism; Genetic effects; Genotype; Goat; Goats; Goats - genetics; Growth factors; growth traits; Height; indel; INDEL Mutation; Insulin; Insulin-like growth factor-binding protein 3; Molecular biology; Period 1 protein; Period 2 protein; Period 3 protein; Period circadian regulator (PER); Phenotype; Polymorphism; Polymorphism, Genetic; Repressors; Transcription factors; Goat; growth traits; indel; circadian genes; Period circadian regulator (PER)
• ISSN: 1049-5398; 1532-2378
• DOI: 10.1080/10495398.2021.1998091

The Period circadian regulator (PER) gene family, including PER1, PER2 and PER3, codes transcriptional repressors which could accurately control biological rhythms. PER1/2 gene was proved to be associated with bone mass and PER1 gene was associated with insulin-like growth factor binding proteins 3 (IGFBP3) levels in serum. However, it was few studies reported genetic effects of PER gene on growth traits at the individual level. In this study, we identified the potential insertion/deletion (indel) loci in PER1/2/3 gene, and then explored the relationship between goat growth traits and the frequency of genotype in Shaanbei white cashmere goats (n = 827). As a result, a 9 bp indel within PER1 gene (g.27528003-27528011 del.TGCTGCTGC; rs642467689) was identified using molecular biology techniques. In addition, there existed significant correlation between the 9 bp indel and body height, height at hip cross, chest depth, body length index and cannon circumference index of goats. These results suggested that the 9 bp indel variation in PER1 gene was associated with goat growth traits, providing the theoretical basic for the role of PER1 gene in goat breeding.