Effects of cholesterol on viability and (n - 6) fatty acid metabolism in cultured human monocyte-like cells (U937)

• Published in: Biochemistry and cell biology Vol. 70; no. 8; p. 643
• Main Authors: Howie, A, Huang, Y S, Horrobin, D F
• Format: Journal Article
• Language: English
• Published: Canada 01.08.1992
• Subjects: Cell Death - drug effects; Cell Division - drug effects; Cholesterol - pharmacology; Fatty Acids, Omega-6; Fatty Acids, Unsaturated - metabolism; Fatty Acids, Unsaturated - toxicity; gamma-Linolenic Acid; Humans; Linoleic Acid; Linoleic Acids - pharmacology; Linolenic Acids - pharmacology; Lipid Peroxidation - drug effects; Monocytes - drug effects; Tumor Cells, Cultured

Effects of supplementation of growth-promoting cholesterol on metabolism of the cytotoxic (n - 6) polyunsaturated fatty acids in cultured human monocyte-like cells (U937) have been examined. U937 cells were incubated in 5% delipidated fetal bovine serum containing 0 or 38.7 microM cholesterol. The r...