Aptamer-modified chitosan-capped mesoporous silica nanoparticles for co-delivery of cytarabine and daunorubicin in leukemia

• Published in: International journal of pharmaceutics Vol. 646; p. 123495
• Main Authors: Heydari, Seyed Reza, Ghahremani, Mohammad Hossein, Atyabi, Fatemeh, Bafkary, Reza, Jaafari, Mahmoud Reza, Dinarvand, Rassoul
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.11.2023
• Subjects: Anticancer drug delivery; Aptamer; Cytarabine; Daunorubicin; Leukemia; Mesoporous silica nanoparticles; Mesoporous silica nanoparticles; Aptamer; Daunorubicin; Cytarabine; Leukemia; Anticancer drug delivery

[Display omitted] •Surface modified mesoporous silica nanoparticles (MSNs) were prepared for targeted delivery of anticancer agents against leukemia cancer cell lines.•The MSNs were surface modified with pH and glutathione sensitive chitosan to control drug release.•The conjugation of the KK1B10 apt...