Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

• Published in: Nature immunology Vol. 14; no. 3; pp. 238 - 245
• Main Authors: Wakim, Linda M, Gupta, Nishma, Mintern, Justine D, Villadangos, Jose A
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2013; Nature Publishing Group
• Subjects: 631/250/1619/554/1834; 631/250/2152/1566/1571; 631/250/255/2514; 631/250/347; Animals; Biomedicine; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - virology; DNA Methylation; Immunologic Memory; Immunology; Infectious Diseases; Interferon-alpha - metabolism; Lung - immunology; Lung - virology; Membrane Proteins - immunology; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Orthomyxoviridae - immunology; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - metabolism; Orthomyxoviridae Infections - virology; Pathogens; Respiratory Mucosa - immunology; Respiratory Mucosa - virology; RNA Interference; RNA, Small Interfering

Villadangos and colleagues show that lung resident memory CD8 + T cells selectively maintain expression of IFITM3, a protein that confers broad resistance to viral infection. Infection with influenza virus results in the deposition of anti-influenza CD8 + resident memory T cells (T RM cells) in the...