The effect of losartan on range of motion and rates of manipulation in total knee arthroplasty: a retrospective matched cohort study

• Published in: Archives of orthopaedic and trauma surgery Vol. 143; no. 7; pp. 4043 - 4048
• Main Authors: Arraut, Jerry, Lygrisse, Katherine A., Singh, Vivek, Fiedler, Benjamin, Schwarzkopf, Ran, Rozell, Joshua C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2023; Springer Nature B.V
• Subjects: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arthroplasty, Replacement, Knee; Cohort analysis; Cohort Studies; Humans; Joint Diseases - surgery; Joint replacement surgery; Knee Joint - surgery; Losartan - therapeutic use; Medicine; Medicine & Public Health; Orthopaedic Surgery; Orthopedics; Prospective Studies; Range of motion; Range of Motion, Articular; Retrospective Studies; Treatment Outcome; Total knee arthroplasty; Range of motion; Manipulation under anesthesia; Losartan; Arthrofibrosis

Introduction Arthrofibrosis remains a common cause of patient dissatisfaction and reoperation after total knee arthroplasty (TKA). Losartan is an angiotensin receptor blocker (ARB) with inhibitory effects on transforming growth factor beta, previously implicated in tissue repair induced fibrosis, an...