Colon-targeted delivery of tacrolimus using pH-responsive polymeric nanoparticles for murine colitis therapy

• Published in: International journal of pharmaceutics Vol. 606; p. 120836
• Main Authors: Cai, Xiaoran, Wang, Xiaolei, He, Muye, Wang, Yan, Lan, Minbo, Zhao, Yuzheng, Gao, Feng
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.09.2021
• Subjects: Inflammatory bowel diseases; Oral nanoparticle delivery system; pH-responsive; Tacrolimus; Targeted drug delivery; HCh NPs; ECh NPs; Targeted drug delivery; Inflammatory bowel diseases; Oral nanoparticle delivery system; Tacrolimus; PDI; pH-responsive; EHCh NPs; Ch NPs

[Display omitted] The present study aimed at constructing an oral nanoparticle delivery system loaded with tacrolimus (FK506) for effective treatment of inflammatory bowel disease. A FK506/HP-β-CD inclusion compound was prepared by grinding to increase drug solubility. To address the side- effects i...