Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease

• Published in: The Journal of experimental medicine Vol. 221; no. 12
• Main Authors: Tejedor Vaquero, Sonia, Neuman, Hadas, Comerma, Laura, Marcos-Fa, Xavi, Corral-Vazquez, Celia, Uzzan, Mathieu, Pybus, Marc, Segura-Garzón, Daniel, Guerra, Joana, Perruzza, Lisa, Tachó-Piñot, Roser, Sintes, Jordi, Rosenstein, Adam, Grasset, Emilie K., Iglesias, Mar, Gonzalez Farré, Monica, Lop, Joan, Patriaca-Amiano, Maria Evangelina, Larrubia-Loring, Monica, Santiago-Diaz, Pablo, Perera-Bel, Júlia, Berenguer-Molins, Pau, Martinez Gallo, Monica, Martin-Nalda, Andrea, Varela, Encarna, Garrido-Pontnou, Marta, Grassi, Fabio, Guarner, Francisco, Mehandru, Saurabh, Márquez-Mosquera, Lucia, Mehr, Ramit, Cerutti, Andrea, Magri, Giuliana
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 02.12.2024
• Subjects: Adult; Akkermansia - immunology; Female; Gastrointestinal Microbiome - immunology; Homeostasis - immunology; Humans; Immunoglobulin A - immunology; Immunoglobulin A - metabolism; Immunoglobulin A, Secretory - immunology; Immunoglobulin A, Secretory - metabolism; Inflammatory Bowel Diseases - immunology; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Leukemia & Lymphoma; Lymphocyte Biology; Male; Plasma Cells - immunology; Plasma Cells - metabolism

The human gut includes plasma cells (PCs) expressing immunoglobulin A1 (IgA1) or IgA2, two structurally distinct IgA subclasses with elusive regulation, function, and reactivity. We show here that intestinal IgA1+ and IgA2+ PCs co-emerged early in life, comparably accumulated somatic mutations, and...