Long-Term Safety and Efficacy of Topical Cyclosporine in 156 Children with Vernal Keratoconjunctivitis

• Published in: International journal of immunopathology and pharmacology Vol. 23; no. 3; pp. 865 - 871
• Main Authors: Pucci, N., Caputo, R., Mori, F., De Libero, C., Di Grande, L., Massai, C., Bernardini, R., Novembre, E.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2010
• Subjects: Administration, Topical; Adolescent; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Child; Child, Preschool; Conjunctiva - pathology; Conjunctivitis, Allergic - drug therapy; Conjunctivitis, Allergic - pathology; Creatine - blood; Cyclosporine - administration & dosage; Cyclosporine - adverse effects; Cyclosporine - therapeutic use; Female; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Long-Term Care; Male; Ophthalmic Solutions; Recurrence; Treatment Outcome; ocular score; eye drops; vernal keratoconjunctivitis; topical cyclosporine; children

Vernal keratoconjunctivitis (VKC) is a chronic and potentially sight-threatening disease. Topical corticosteroids (Cs) seem to be the only effective treatment for this condition, although severe side effects may occur owing to their prolonged use. More recently, cyclosporine (Cyc) eye drops have bee...