Structural insights and cytotoxicity evaluation of benz[e]indole pyrazolyl-substituted amides

• Published in: Molecular diversity Vol. 28; no. 3; pp. 1363 - 1376
• Main Authors: Ramle, Abdul Qaiyum, Chan, Nadia Nabihah Mohd Yusof, Ng, Min Phin, Tan, Chun Hoe, Sim, Kae Shin, Tiekink, Edward R. T., Fei, Chee Chin
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2024; Springer Nature B.V
• Subjects: Amides - chemistry; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biochemistry; Biomedical and Life Sciences; Cell Line, Tumor; Cell Survival - drug effects; Crystallography, X-Ray; HCT116 Cells; Humans; Indoles - chemistry; Indoles - pharmacology; Life Sciences; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Organic Chemistry; Original Article; Pharmacy; Polymer Sciences; Pyrazoles - chemistry; Pyrazoles - pharmacology; Structure-Activity Relationship; Toxicity; X-ray crystallography; Cytotoxicity; DFT; Minor groove binding

Five new compounds of benz[ e ]indole pyrazolyl-substituted amides ( 2a–e ) were synthesised in low to good yields via the direct amide-coupling reaction between a pyrazolyl derivative containing a carboxylic acid and several amine substrates. The molecular structures were determined by various spec...