Metabolic kinetic modeling of [11C]methionine based on total-body PET in multiple myeloma

• Published in: European journal of nuclear medicine and molecular imaging Vol. 50; no. 9; pp. 2683 - 2691
• Main Authors: Li, Jiajin, Ni, Beiwen, Yu, Xiaofeng, Wang, Cheng, Li, Lianghua, Zhou, Yun, Gu, Yue, Huang, Gang, Hou, Jian, Liu, Jianjun, Chen, Yumei
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2023; Springer Nature B.V
• Subjects: Amino acids; Bone Marrow - pathology; Cardiology; Goodness of fit; Hematology; Humans; Imaging; Immunoglobulins; Lesions; M protein; Medicine; Medicine & Public Health; Metabolism; Methionine; Modelling; Multiple myeloma; Multiple Myeloma - diagnostic imaging; Multiple Myeloma - pathology; Noninvasive evaluation; Nuclear Medicine; Oncology; Original Article; Orthopedics; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Proteins; Racemethionine; Radioactive tracers; Radiology; Serum levels; uEXPLORER; multiple myeloma; [; C] methionine; PET/CT; kinetic modeling; [11C] methionine

Purpose Multiple myeloma (MM) is a malignant disease characterized by the secretion of monoclonal immunoglobulins and has a high demand for amino acids. [ 11 C]methionine total-body PET is capable of noninvasive dynamic monitoring of radiotracer in vivo, thus providing a way to reveal the dynamic ch...