Mechanism of electrocardiographic T-wave flattening in diabetes mellitus: experimental and simulation study

• Published in: Physiological research Vol. 66; no. 5; pp. 781 - 789
• Main Authors: Sedova, K A, Azarov, J E, Arteyeva, N V, Ovechkin, A O, Vaykshnorayte, M A, Vityazev, V A, Bernikova, O G, Shmakov, D N, Kneppo, P
• Format: Journal Article
• Language: English
• Published: Czech Republic Institute of Physiology 01.01.2017
• Subjects: Animals; Blood Glucose - metabolism; Body Surface Potential Mapping - methods; Cardiac arrhythmia; Chest; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - physiopathology; Electrocardiography; Electrocardiography - methods; Female; Heart; Laboratory animals; Male; Mathematical models; Rabbits; Rodents; Studies; Ventricle

In the present study we investigated the contribution of ventricular repolarization time (RT) dispersion (the maximal difference in RT) and RT gradients (the differences in RT in apicobasal, anteroposterior and interventricular directions) to T-wave flattening in a setting of experimental diabetes m...