Immune, endocrine, and psychological responses in civilians displaced by war
The objectives of this study were to assess the influence of trauma caused by forced expulsion from home in a war-ravaged region on the psychological, hormonal, and immune responses in displaced persons and to analyze the relationships between psychometric, hormonal, and immunologic variables. Parti...
Saved in:
Published in | Psychosomatic medicine Vol. 62; no. 4; p. 502 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.07.2000
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | The objectives of this study were to assess the influence of trauma caused by forced expulsion from home in a war-ravaged region on the psychological, hormonal, and immune responses in displaced persons and to analyze the relationships between psychometric, hormonal, and immunologic variables.
Participants were 20 displaced and 14 control women. Psychosomatic response was evaluated using the COR-NEX2 test. Serum concentrations of cortisol, prolactin, endorphin, thyroxine, and triiodothyronine were measured by radioimmunoassay. Immunophenotyping and lymphocyte proliferation were determined by flow cytometry, and phagocyte functions (i.e., ingestion and antibody-dependent cytotoxicity) against 51Cr-labeled sheep red blood cells were assessed through radioactivity uptake and release, respectively.
In comparison with control women, displaced women had higher COR-NEX2 test scores; higher serum cortisol, prolactin, and endorphin levels; an increase in activated phenotype within all three measured cell populations (i.e., B, T, and natural killer cells); as well as an enhanced proportion of proliferating lymphocytes in freshly isolated samples. However, the phytohemagglutinin-stimulated proliferative response, estimated as the stimulation index, was lower in displaced women. A complex pattern of relations between psychological, hormonal, and immune responses was observed.
Chronic psychological stress elicited multiple, predominantly stimulatory influences on immune functions. |
---|---|
AbstractList | The objectives of this study were to assess the influence of trauma caused by forced expulsion from home in a war-ravaged region on the psychological, hormonal, and immune responses in displaced persons and to analyze the relationships between psychometric, hormonal, and immunologic variables.
Participants were 20 displaced and 14 control women. Psychosomatic response was evaluated using the COR-NEX2 test. Serum concentrations of cortisol, prolactin, endorphin, thyroxine, and triiodothyronine were measured by radioimmunoassay. Immunophenotyping and lymphocyte proliferation were determined by flow cytometry, and phagocyte functions (i.e., ingestion and antibody-dependent cytotoxicity) against 51Cr-labeled sheep red blood cells were assessed through radioactivity uptake and release, respectively.
In comparison with control women, displaced women had higher COR-NEX2 test scores; higher serum cortisol, prolactin, and endorphin levels; an increase in activated phenotype within all three measured cell populations (i.e., B, T, and natural killer cells); as well as an enhanced proportion of proliferating lymphocytes in freshly isolated samples. However, the phytohemagglutinin-stimulated proliferative response, estimated as the stimulation index, was lower in displaced women. A complex pattern of relations between psychological, hormonal, and immune responses was observed.
Chronic psychological stress elicited multiple, predominantly stimulatory influences on immune functions. |
Author | Sabioncello, A Matijević, L Kocijan-Hercigonja, D Jeren, T Tomasić, J Rijavec, M Dekaris, D Rabatić, S |
Author_xml | – sequence: 1 givenname: A surname: Sabioncello fullname: Sabioncello, A email: ante.sabioncello@imz.tel.hr organization: Institute of Immunology, Zagreb, Croatia. ante.sabioncello@imz.tel.hr – sequence: 2 givenname: D surname: Kocijan-Hercigonja fullname: Kocijan-Hercigonja, D – sequence: 3 givenname: S surname: Rabatić fullname: Rabatić, S – sequence: 4 givenname: J surname: Tomasić fullname: Tomasić, J – sequence: 5 givenname: T surname: Jeren fullname: Jeren, T – sequence: 6 givenname: L surname: Matijević fullname: Matijević, L – sequence: 7 givenname: M surname: Rijavec fullname: Rijavec, M – sequence: 8 givenname: D surname: Dekaris fullname: Dekaris, D |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10949095$$D View this record in MEDLINE/PubMed |
BookMark | eNo1j1tLxDAQhfOw4l70L0h-gNHJpWn6KIuXhYIv-rxM06lG2rQ0rtJ_b4t64HA-DszA2bJV7CMxxiXcSCjyW5hlnVFCLZTPFgu4FdsAaC20zM2abVP6mFtTaHXO1vOhKaDINqw8dN0p0jWnWPd-DAtirPmQJv_et_1b8NjykdLQx0SJh8h9-AptwJh4HdLQoqeaVxP_xvGCnTXYJrr8yx17fbh_2T-J8vnxsL8rhddGfQrtETOQhsDoCmxWKEfUANo8U2idq4wG2aCyZHUBSPM8KX1uM1U5DcqpHbv6_Tucqo7q4zCGDsfp-D9L_QCpIE97 |
CitedBy_id | crossref_primary_10_1016_j_pnpbp_2004_01_009 crossref_primary_10_1016_j_psyneuen_2024_107084 crossref_primary_10_3389_fimmu_2021_815840 crossref_primary_10_33145_2304_8336_2023_28_286_315 crossref_primary_10_22141_2224_0586_20_1_2024_1652 crossref_primary_10_1016_j_psychres_2020_113661 crossref_primary_10_1177_1363461507081639 crossref_primary_10_1097_00006842_200201000_00004 crossref_primary_10_1016_j_biopsych_2003_11_018 crossref_primary_10_1016_j_cccn_2003_12_019 crossref_primary_10_1037_0033_2909_130_4_601 crossref_primary_10_3109_14767058_2012_664201 crossref_primary_10_1016_S0889_1591_03_00058_8 crossref_primary_10_1017_S1049023X23006702 crossref_primary_10_1034_j_1601_5215_2002_140601_x crossref_primary_10_1038_tp_2017_14 crossref_primary_10_1016_j_bbi_2014_06_003 crossref_primary_10_1017_S0924270800032725 crossref_primary_10_1111_j_1365_2249_2007_03410_x crossref_primary_10_1016_j_canep_2015_06_003 crossref_primary_10_1016_j_socscimed_2020_113070 crossref_primary_10_1016_S0140_6736_02_07345_2 crossref_primary_10_1111_ijn_12272 crossref_primary_10_1146_annurev_clinpsy_080921_080359 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/00006842-200007000-00008 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
ExternalDocumentID | 10949095 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Croatia |
GeographicLocations_xml | – name: Croatia |
GroupedDBID | --- --Z .-D .55 .GJ .Z2 01R 0R~ 123 18M 1J1 2WC 3O- 40H 41~ 4Q1 4Q2 4Q3 53G 5RE 5VS 6PF 71W 77Y 7O~ 85S AAAAV AAAXR AAGIX AAHPQ AAIKC AAIQE AAMNW AAMOA AAMTA AAQKA AAQQT AARTV AASCR AASOK AAWTL AAXQO AAYEP AAYJJ ABASU ABBUW ABDIG ABIVO ABJNI ABVCZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACHQT ACILI ACNCT ACNWC ACPRK ACWDW ACWRI ACXJB ACXNZ ADCBW ADFPA ADGGA ADHPY ADNKB AE6 AEETU AENEX AFDTB AFUWQ AGINI AHMBA AHOMT AHQNM AHRYX AHVBC AIJEX AINUH AJIOK AJNWD AJNYG AJZMW AKULP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BOYCO BQLVK BS7 C45 CGR CS3 CUY CVF DIWNM DU5 DUNZO E.X EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 GNXGY GQDEL H0~ HLJTE HZ~ H~9 IH2 IKREB IKYAY IN~ JK3 JK8 K8S KD2 KMI L-C MVM N4W N9A NPM N~7 N~B N~M O9- OAG OAH OCUKA ODA OHT OL1 OLH OLU OLV OLW OLY OLZ OMH OPUJH OPX ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OWU OWV OWW OWX OWY OWZ OXXIT P2P PQQKQ R58 RLZ S10 S4R S4S TEORI TR2 TSPGW V2I VQA VVN W3M W8F WH7 WOQ WOW X3V X3W X7M XJT XOL XXN XYM YBU YNT YOC YYM ZFV ZHY ZXP ZZMQN ~9M |
ID | FETCH-LOGICAL-c342t-3caa5014e043b065928eef0a6752a688b4301fa26e6390ae06811c7652b830282 |
ISSN | 0033-3174 |
IngestDate | Sat Sep 28 08:40:29 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c342t-3caa5014e043b065928eef0a6752a688b4301fa26e6390ae06811c7652b830282 |
PMID | 10949095 |
ParticipantIDs | pubmed_primary_10949095 |
PublicationCentury | 2000 |
PublicationDate | 2000-07-01 |
PublicationDateYYYYMMDD | 2000-07-01 |
PublicationDate_xml | – month: 07 year: 2000 text: 2000-07-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Psychosomatic medicine |
PublicationTitleAlternate | Psychosom Med |
PublicationYear | 2000 |
SSID | ssj0004932 |
Score | 1.8172535 |
Snippet | The objectives of this study were to assess the influence of trauma caused by forced expulsion from home in a war-ravaged region on the psychological,... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 502 |
SubjectTerms | Adolescent Adult Antibody-Dependent Cell Cytotoxicity - immunology Arousal - physiology Croatia Female Hormones - blood Humans Immune Tolerance - immunology Immunophenotyping Lymphocyte Activation - immunology Lymphocyte Subsets - immunology Personality Inventory Phagocytosis - immunology Psychophysiologic Disorders - diagnosis Psychophysiologic Disorders - physiopathology Psychophysiologic Disorders - psychology Refugees - psychology Stress Disorders, Post-Traumatic - diagnosis Stress Disorders, Post-Traumatic - physiopathology Stress Disorders, Post-Traumatic - psychology Warfare |
Title | Immune, endocrine, and psychological responses in civilians displaced by war |
URI | https://www.ncbi.nlm.nih.gov/pubmed/10949095 |
Volume | 62 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELZaWFgQiPdLHthoUBI7rxEhUKmgA7RSt8p2HNRKpFVbQLDyxznbSZqUgoAlSmPVinNfLue7--4QOmUxfDQ5bHKE58QWFbFjRcRjVsIpIzIJEu4ocvJd2292aavn9Wq1j1LW0vOMn4v3pbyS_0gVroFcFUv2D5ItJoULcA7yhSNIGI6_kvGNIndoj6RM45GYDMwPzf2vKLaJyYTVyVdnYvAyUM6NqYrO6JwsbYS-sknZUjWacToyJV0XQ_APjGvCYxa5mettkPWQpVZTNXJ6HKVDVskqvmccptMGbFDxu3ZUmlJpoFXxRthF5mqhYYni65nOO7mG9d0SkmhJXXqabf1VjZvywPpbGir6kA64Zhx4XQZiVpLu-EmLF_5EI9t07Px5dKHAdj5UR_UgVEqyrRw-ObU2IqbgfLasLBksr_u57PZUHdpsyoW9irZZOhtoPdts4AuDnE1Uk-kWujWoaeACMw0MiMEVxOACMXiQ4gIxuEAM5m8YELONutdXncumlfXUsASh7swigjEVSpY2JVzH1EMpE5vBvtFlfhhyCho_Ya4vwXS1mYQVOo4IfM_lqlJc6O6glXSUyj2EExLxhEoBNrBP4YXnfhCr7gwEjEgRBe4-2jWL749N4ZR-_lgOvh05RGtzVB2h1QTeVHkMZt-Mn2jBfAKot08X |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immune%2C+endocrine%2C+and+psychological+responses+in+civilians+displaced+by+war&rft.jtitle=Psychosomatic+medicine&rft.au=Sabioncello%2C+A&rft.au=Kocijan-Hercigonja%2C+D&rft.au=Rabati%C4%87%2C+S&rft.au=Tomasi%C4%87%2C+J&rft.date=2000-07-01&rft.issn=0033-3174&rft.volume=62&rft.issue=4&rft.spage=502&rft_id=info:doi/10.1097%2F00006842-200007000-00008&rft_id=info%3Apmid%2F10949095&rft_id=info%3Apmid%2F10949095&rft.externalDocID=10949095 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0033-3174&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0033-3174&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0033-3174&client=summon |