Photofrin as a specific radiosensitizing agent for tumors: studies in comparison to other porphyrins, in an experimental in vivo model

• Published in: Journal of photochemistry and photobiology. B, Biology Vol. 66; no. 3; pp. 157 - 164
• Main Authors: Schaffer, M., Schaffer, P.M., Corti, L., Gardiman, M., Sotti, G., Hofstetter, A., Jori, G., Dühmke, E.
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.04.2002
• Subjects: Animals; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - therapeutic use; Dihematoporphyrin Ether - pharmacokinetics; Dihematoporphyrin Ether - therapeutic use; Female; Humans; Ionizing irradiation; Mice; Mice, Nude; Photofrin II; Photosensitizer; Porphyrins; Porphyrins - therapeutic use; Radiation-Sensitizing Agents - therapeutic use; Radiosensitizer; Radiotherapy Dosage; Tissue Distribution; Transplantation, Heterologous; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - pathology; Radiosensitizer; Ionizing irradiation; Photofrin II; Photosensitizer; Porphyrins

The use of ionizing radiation for tumor treatment represents a well established therapeutic modality. The efficiency and selectivity of radiotherapeutic protocols can be often enhanced by the addition of specific chemical compounds that optimise the response of the tumor to the incident radiation as...