Association between polymorphism at codon 469 of the ICAM-1 gene and Henoch-Schönlein purpura in an Iranian cohort

• Published in: Nucleosides, nucleotides & nucleic acids Vol. 44; no. 3; pp. 259 - 266
• Main Authors: Salehi, Shima, Hozhabrpour, Amir, Takrim Nojehdeh, Somayeh, Mojbafan, Marzieh
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 04.03.2025; Taylor & Francis Ltd
• Subjects: Adolescent; Case-Control Studies; Cell adhesion; Child; Codon - genetics; Cohort Studies; Female; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Henoch-Schönlein purpura; Humans; ICAM-1; IgA Vasculitis - genetics; Intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - genetics; Iran; Male; polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population studies; Purpura; Rheumatology; Schonlein-Henoch purpura; Iran; Henoch-Schönlein purpura; ICAM-1; polymorphism; Iran

Henoch-Schönlein purpura (HSP) is a common form of IgA1-mediated blood vessel inflammation affecting mainly children. Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been shown to be associated with HSP in different populations; in this study, we investigated its potential associa...