A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent - Klein, Misha; Das, Arnab; Bera, Subhas C; Anderson, Thomas K; Kocincova, Dana; Lee, Hery W; Wang, Bing; Papini, Flavia S; Marecki, John C; Arnold, Jamie J; Cameron, Craig E; Raney, Kevin D; et al. (Nucleic acids research, 2025)
Keywords: Coronavirus RNA-Dependent RNA Polymerase - chemistry; Coronavirus RNA-Dependent RNA Polymerase - genetics; Coronavirus RNA-Dependent RNA Polymerase - metabolism; Humans; Nucleic Acid Enzymes; Protein Conformation; RNA, Viral - biosynthesis; RNA, Viral - genetics; RNA, Viral - metabolism; RNA-Dependent RNA Polymerase - chemistry; RNA-Dependent RNA Polymerase - genetics; RNA-Dependent RNA Polymerase - metabolism; SARS-CoV-2 - enzymology; SARS-CoV-2 - genetics; SARS-CoV-2 - physiology; Transcription Elongation, Genetic; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Virus Replication - genetics