Biodistribution and radiation dosimetry in cancer patients of the ascorbic acid analogue 6-Deoxy-6-[18F] fluoro-L-ascorbic acid PET imaging: first-in-human study

• Published in: European journal of nuclear medicine and molecular imaging Vol. 50; no. 10; pp. 3072 - 3083
• Main Authors: Long, Yali, Yi, Chang, Wu, Renbo, Zhang, Yuying, Zhang, Bing, Shi, Xinchong, Zhang, Xiangsong, Zha, Zhihao
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2023; Springer Nature B.V
• Subjects: Acids; Adrenal glands; Animals; Ascorbic acid; Cancer; Cancer research; Cardiology; Choroid plexus; Computed tomography; Dosimeters; Dosimetry; Fluorine isotopes; Human performance; Humans; Imaging; Kidneys; Liver; Localization; Medical imaging; Medical research; Medicine; Medicine & Public Health; Mice; Neoplasms - diagnostic imaging; Nuclear Medicine; Oncology; Original Article; Orthopedics; Patients; Pharmaceuticals; Pituitary; Pituitary gland; Positron emission; Positron Emission Tomography Computed Tomography - methods; Positron-Emission Tomography - methods; Radiation; Radiochemistry; Radioisotopes; Radiology; Radiometry; Tissue Distribution; Tumors; L-ascorbic acid; [; Dosimetry; F]DFA; Biodistribution; PET/CT; [18F]DFA

Purpose Clinical studies on the use of ascorbic acid (AA) have become a hot spot in cancer research. There remains an unmet need to assess AA utilization in normal tissues and tumors. 6-Deoxy-6-[ 18 F]fluoro-L-ascorbic acid ([ 18 F]DFA) displayed distinctive tumor localization and similar distributi...