Applying Meta-Analytic-Predictive Priors with the R Bayesian Evidence Synthesis Tools

• Published in: Journal of statistical software Vol. 100; no. 19; pp. 1 - 32
• Main Authors: Weber, Sebastian, Li, Yue, III, John W. Seaman, Kakizume, Tomoyuki, Schmidli, Heinz
• Format: Journal Article
• Language: English
• Published: Foundation for Open Access Statistics 01.11.2021
• Subjects: bayesian inference; clinical trial; extrapolation; historical control; operating characteristics; prior; probability of success; robust analysis

Use of historical data in clinical trial design and analysis has shown various advantages such as reduction of number of subjects and increase of study power. The metaanalytic-predictive (MAP) approach accounts with a hierarchical model for between-trial heterogeneity in order to derive an informati...