High levels of gut-homing immunoglobulin A+ B lymphocytes support the pathogenic role of intestinal mucosal hyperresponsiveness in immunoglobulin A nephropathy patients

• Published in: Nephrology, dialysis, transplantation Vol. 36; no. 3; pp. 452 - 464
• Main Authors: Sallustio, Fabio, Curci, Claudia, Chaoul, Nada, Fontò, Giulia, Lauriero, Gabriella, Picerno, Angela, Divella, Chiara, Di Leo, Vincenzo, De Angelis, Maria, Ben Mkaddem, Sanae, Macchia, Luigi, Gallone, Anna, Monteiro, Renato C, Pesce, Francesco, Gesualdo, Loreto
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 20.02.2021
• Subjects: Adult; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; B-Lymphocytes - pathology; Case-Control Studies; Cytokines - metabolism; Female; Gastrointestinal Microbiome - immunology; Glomerulonephritis, IGA - complications; Humans; Immunity, Mucosal - immunology; Immunoglobulin A - blood; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Male; Middle Aged; Original; IgA nephropathy; B cells; commensal bacteria; glomerulonephritis; gut microbiota

Abstract Background Immunoglobulin A nephropathy (IgAN) is the most frequent primary glomerulonephritis. The role of the microbiota and mucosal immunity in the pathogenesis of IgAN remains a key element. To date, the hypothetical relationship between commensal bacteria, elevated tumour necrosis fact...