Comprehensive analysis of proton pump inhibitors and risk of digestive tract cancers

• Published in: European journal of cancer (1990) Vol. 156; pp. 190 - 201
• Main Authors: Zeng, Ruijie, Cheng, Yunjiu, Luo, Dongling, Wang, Jinghua, Yang, Jun, Jiang, Lei, Zhuo, Zewei, Guo, Kehang, Wu, Huihuan, Leung, Felix W., Sha, Weihong, Chen, Hao
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.2021; Elsevier Science Ltd
• Subjects: Cancer; Carcinogens; Causality; Causation; Colorectal cancer; Colorectal carcinoma; Confidence intervals; Criteria; Digestive tract cancer; Dose; Duration; Esophageal cancer; Esophagus; Evaluation; Gastric cancer; Gastrointestinal tract; Liver cancer; Meta-analysis; Pancreatic cancer; Polynomials; Proton pump inhibitor; Proton pump inhibitors; Protons; Risk; Risk assessment; Duration; Digestive tract cancer; Dose; Proton pump inhibitor

For the past two decades, dispute on whether proton pump inhibitor (PPI) leads to digestive tract cancer remains, and emerging studies in recent years still demonstrate inconsistent results, which continues to perpetuate concerns over the safety of PPI use. We performed a systematic review and meta-...