Unraveling the clinical–pathological correlations of subjects with isolated and mixed neurodegenerative processes in the National Alzheimer’s Coordinating Center dataset

• Published in: Journal of neuropathology and experimental neurology Vol. 84; no. 3; pp. 177 - 194
• Main Authors: Hiya, Satomi, Maldonado-Díaz, Carolina, Rohde, Susan K, Gonzales, Mitzi M, Canbeldek, Leyla, Kulumani Mahadevan, Lakshmi S, Yokoda, Raquel T, Sullivan, A Campbell, Parker, Alicia S, White, Charles L, Daoud, Elena V, Flores-Almazan, Victoria, Crary, John F, Farrell, Kurt, Walker, Jamie M, Richardson, Timothy E
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 21.02.2025
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - epidemiology; Alzheimer Disease - pathology; Brain - pathology; Cohort Studies; Female; Humans; Male; Middle Aged; Neurodegenerative Diseases - epidemiology; Neurodegenerative Diseases - pathology; Original; cerebrovascular disease (CVD); limbic-predominant age-related TDP-43 encephalopathy (LATE-NC); Lewy body dementia (LBD); Pick disease (PiD); frontotemporal lobar dementia (FTLD-TDP); primary age-related tauopathy (PART); Alzheimer disease neuropathologic change (ADNC)

Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, the presence of multiple comorbid neuropathologies is increasingly being recognized as a major contributor to the worldwide dementia burden. We analyzed 1051 subjects with specific com...