Successful treatment of refractory thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus with combination of plasma exchange and low-dose rituximab

• Published in: Lupus Vol. 29; no. 14; pp. 1961 - 1967
• Main Authors: Ma, Wanlu, Bai, Wei, Wu, Xueyan, Zhao, Jiuliang, Li, Mengtao, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.12.2020; Sage Publications Ltd
• Subjects: Apheresis; Corticosteroids; Immunomodulators; Immunosuppressive agents; Immunotherapy; L-Lactate dehydrogenase; Lactic acid; Lupus; Lymphocytes B; Methylprednisolone; Monoclonal antibodies; Non-Hodgkin's lymphoma; Patients; Peripheral blood; Platelets; Proteinuria; Purpura; Rituximab; Systemic lupus erythematosus; Targeted cancer therapy; Thrombocytopenia; Thrombocytopenic purpura; Thrombotic thrombocytopenic purpura; Thrombotic thrombocytopenic purpura; systemic lupus erythematosus; low-dose rituximab; prognosis

Objectives Thrombotic thrombocytopenia purpura (TTP) associated with systemic lupus erythematous (SLE) (i.e., SLE-TTP) is a rare life-threatening disease often requiring intensive immunosuppressive agents, in addition to high-dose corticosteroids and plasma exchange (PEX). The optimal therapy of rit...