Blocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB signaling axis - Cao, Canhui; Xu, Miaochun; Peng, Ting; Liu, Xiaojie; Lin, Shitong; Xu, Yashi; Chu, Tian; Liu, Shiyi; Wu, Ping; Hu, Bai; Ding, Wencheng; Li, Li; et al. (Genome medicine, 2025)
Keywords: Animal models; Antagonists; Breast cancer; Cancer immunotherapy; CD4 antigen; CD8 antigen; Cells; Cervical cancer; Chemokines; Clinical trials; CXCR4; CXCR4 protein; Genotype & phenotype; Guanine nucleotide-binding protein; Guanosine triphosphatases; Hospitals; Immunosuppression; Immunotherapy; Laboratory animals; Lymphocytes; Lymphocytes T; Molecular modelling; NF-κB protein; NF-κB2; Organoids; Ovarian cancer; Patients; Penicillin; Phenotypes; Regulatory T (Treg) cells; Review boards; Rho GTPase pathway; Squamous cell carcinoma; Transcriptomics; Tumor microenvironment; Tumors; China